SHARPIN 抗体 (AA 260-310) (Alexa Fluor 350)
-
- 抗原 See all SHARPIN 抗体
- SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))
-
抗原表位
- AA 260-310
-
适用
- 人, 大鼠, 小鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This SHARPIN antibody is conjugated to Alexa Fluor 350
-
应用范围
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human SHARPIN
- 亚型
- IgG
- Top Product
- Discover our top product SHARPIN Primary Antibody
-
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 82-171) antibody
SHARPIN 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 1-326) antibodySHARPIN 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 51-148) antibodySHARPIN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 301-350) antibodySHARPIN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 1-170) antibodySHARPIN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (C-Term) antibodySHARPIN 适用: 人, 大鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- IF(IHC-P) 1:50-200
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
-
- 抗原
- SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))
- 别名
- SHARPIN (SHARPIN 产品)
- 别名
- 0610041B22Rik antibody, AW121341 antibody, RBCKL1 antibody, SIPL1 antibody, cpdm antibody, Conneck1 antibody, SHANK-associated RH domain interacting protein antibody, SHANK associated RH domain interactor antibody, SHANK-associated RH domain interactor antibody, Sharpin antibody, SHARPIN antibody
- 背景
-
Synonyms: SIPL1, Sharpin, Shank-associated RH domain-interacting protein, Shank-interacting protein-like 1, hSIPL1, PSEC0216
Background: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
- 基因ID
- 81858
- UniProt
- Q9H0F6
-
