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FBXW7 抗体 (AA 501-600) (Biotin)

This anti-FBXW7 antibody (ABIN1398835) is a Rabbit Polyclonal antibody detecting FBXW7 in WB, ELISA, IHC (p), IHC (fro). Suitable for Human, Mouse, Rat.
产品编号 ABIN1398835
发货至: 中国

Quick Overview for FBXW7 抗体 (AA 501-600) (Biotin) (ABIN1398835)

抗原

See all FBXW7 抗体
FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

适用

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  • 3
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  • 2
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人, 小鼠, 大鼠

宿主

  • 56
  • 12

克隆类型

  • 59
  • 9
多克隆

标记

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  • 1
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This FBXW7 antibody is conjugated to Biotin

应用范围

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  • 24
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  • 9
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  • 1
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Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

    • 14
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 501-600

    交叉反应

    人, 小鼠, 大鼠

    预测反应

    Dog,Cow,Pig,Horse

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human Fbxw7/hCDC4

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

    别名

    Fbxw7

    背景

    Synonyms: AGO, CDC4, FBW6, FBW7, hAgo, FBX30, FBXW6, SEL10, hCdc4, FBXO30, SEL-10, F-box/WD repeat-containing protein 7, Archipelago homolog, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, FBXW7

    Background: Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463).

    基因ID

    55294

    UniProt

    Q969H0

    途径

    Notch Signaling, EGFR Signaling Pathway
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