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Girdin 抗体 (pSer1417) (AbBy Fluor® 488)

This anti-Girdin antibody (ABIN1397448) is a Rabbit Polyclonal antibody detecting Girdin in WB, FACS. Suitable for Human.
产品编号 ABIN1397448
发货至: 中国

Quick Overview for Girdin 抗体 (pSer1417) (AbBy Fluor® 488) (ABIN1397448)

抗原

See all Girdin (CCDC88A) 抗体
Girdin (CCDC88A) (Coiled-Coil Domain Containing 88A (CCDC88A))

适用

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宿主

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克隆类型

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多克隆

标记

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This Girdin antibody is conjugated to AbBy Fluor® 488

应用范围

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Western Blotting (WB), Flow Cytometry (FACS)
  • 抗原表位

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    pSer1417

    交叉反应

    预测反应

    Mouse,Rat,Dog,Cow,Pig,Horse

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic phosphopeptide derived from human Girdin around the phosphorylation site of Ser1417

    亚型

    IgG
  • 应用备注

    FCM 1:20-100

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    Girdin (CCDC88A) (Coiled-Coil Domain Containing 88A (CCDC88A))

    别名

    Girdin

    背景

    Synonyms: APE, GIV, GRDN, HkRP1, GIRDIN, KIAA1212, Akt phosphorylation enhancer, Coiled-coil domain-containing protein 88A, G alpha-interacting vesicle-associated protein, Girders of actin filament, Hook-related protein 1, CCDC88A

    Background: Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.

    基因ID

    55704

    UniProt

    Q3V6T2
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