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Factor 12 Heavy Chain (F12) 抗体

F12 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1387090
发货至: 中国
  • 抗原 See all Factor 12 Heavy Chain (F12) 抗体
    Factor 12 Heavy Chain (F12)
    适用
    人, 小鼠, 大鼠
    宿主
    • 16
    • 1
    克隆类型
    • 16
    • 1
    多克隆
    标记
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    非结合性
    应用范围
    • 17
    • 12
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human Coagulation factor XIIa heavy chain
    亚型
    IgG
  • 应用备注
    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    Factor 12 Heavy Chain (F12)
    别名
    Factor 12 heavy chain (F12 产品)
    别名
    HAF antibody, FXII antibody, HAE3 antibody, HAEX antibody, coagulation factor XII antibody, coagulation factor XII (Hageman factor) antibody, F12 antibody
    背景

    Synonyms: Factor XII, Coagulation factor XII, Factor XII heavy chain, Coagulation factor XIIa heavy chain, F12, F12 deficiency, FA12_HUMAN, Factor XII deficiency, HAE3, HAEX, HAF, HAF deficiency, Hageman factor, Coagulation factor XIIa heavy chain.

    Background: This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008].

    基因ID
    2161
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