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SASS6 抗体

SASS6 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1387012
发货至: 中国
  • 抗原 See all SASS6 抗体
    SASS6 (Spindle Assembly 6 Homolog (SASS6))
    适用
    • 37
    • 17
    • 15
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    • 2
    • 2
    • 2
    • 2
    人, 小鼠, 大鼠
    宿主
    • 35
    • 2
    克隆类型
    • 37
    多克隆
    标记
    • 13
    • 3
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    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
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    This SASS6 antibody is un-conjugated
    应用范围
    • 34
    • 14
    • 12
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human SASS6
    亚型
    IgG
    Top Product
    Discover our top product SASS6 Primary Antibody
  • 应用备注
    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    SASS6 (Spindle Assembly 6 Homolog (SASS6))
    别名
    SASS6 (SASS6 产品)
    别名
    SAS-6 antibody, SAS6 antibody, 2810453L12Rik antibody, RGD1306255 antibody, CG15524 antibody, DSAS-6 antibody, DSas-6 antibody, DSas6 antibody, Dmel\\CG15524 antibody, Dsas6 antibody, Sas-6 antibody, Sas6 antibody, dsas-6 antibody, sas6 antibody, wu:fb98c12 antibody, zgc:55668 antibody, SASS6 antibody, sass6.2 antibody, SAS-6 centriolar assembly protein antibody, Spindle assembly abnormal 6 antibody, spindle assembly 6 homolog L homeolog antibody, SAS-6 centriolar assembly protein L homeolog antibody, SASS6 antibody, Sass6 antibody, Sas-6 antibody, sass6.L antibody, sass6 antibody, sass6.2.L antibody
    背景

    Synonyms: HsSAS 6, HsSAS6, MGC119440, SAS 6, SAS6, SASS 6, Spindle assembly 6 homolog C. elegans, Spindle assembly 6 homolog, Spindle assembly abnormal protein 6 homolog, PJA2_HUMAN.

    Background: SAS-6 (spindle assembly abnormal protein 6 homolog, HsSAS-6) is a 657 amino acid protein encoded by the human gene SAS6. SAS-6 is a component of the centrosome that contains one PISA (present in SAS-6) domain. LK4, SAS-6, CPAP and other centriole related proteins are required at different stages of procentriole formation and were associated with different centriolar structures. SAS-6 associates only transiently with nascent procentrioles, whereas CEP135 and CPAP form a core structure within the proximal lumen of both parental and nascent centrioles. SAS-6 is necessary for procentriole formation in human cell lines and is localized asymmetrically next to the centriole at the onset of procentriole formation. SAS-6 levels oscillate during the cell cycle, it is degraded in mitosis starting at anaphase, and it accumulates again at the end of the following G1 phase. The anaphase-promoting complex targets SAS-6 for degradation by the 26S Proteasome, and a KEN box in the C-terminus of SAS-6 is necessary for its degradation. Increased SAS-6 levels promoted the formation of multiple procentrioles forming next to a single centriole.

    基因ID
    163786
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