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TNF alpha 抗体

This anti-TNF alpha antibody is a 小鼠 单克隆 antibody detecting TNF alpha in ELISA, IHC, Func 和 ELISpot. Suitable for 人. This Primary Antibody has been cited in 15+ publications.
产品编号 ABIN1383955
发货至: 中国

Quick Overview for TNF alpha 抗体 (ABIN1383955)

抗原

See all TNF alpha 抗体
TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This TNF alpha antibody is un-conjugated

应用范围

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ELISA, Immunohistochemistry (IHC), Functional Studies (Func), ELISpot

克隆位点

B-C7
  • 特异性

    Recognises both natural and recombinant human TNF-a

    纯化方法

    Ion exchange chromatography

    过滤

    0.22 μm filtered

    免疫原

    Recombinant human TNF-a,Myeloma X63/AG.8653 x Balb/c spleen cells

    亚型

    IgG1 kappa

    Biological Activity Comment

    Inhibits TNFα induced cytotoxicity on U937 cells
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

    储存液

    Without preservative

    储存条件

    4 °C

    储存方法

    Store at +2-8°C for 12 months. DO NOT FREEZE.
  • Arduise, Abache, Li, Billard, Chabanon, Ludwig, Mauduit, Boucheix, Rubinstein, Le Naour: "Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 10, pp. 7002-13, (2008) (PubMed).

    Venet, Pachot, Debard, Bohe, Bienvenu, Lepape, Powell, Monneret: "Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 9, pp. 6540-7, (2006) (PubMed).

    Dyugovskaya, Lavie, Lavie: "Phenotypic and functional characterization of blood gammadelta T cells in sleep apnea." in: American journal of respiratory and critical care medicine, Vol. 168, Issue 2, pp. 242-9, (2003) (PubMed).

    Limb, Daniels, Pleass, Charteris, Luthert, Khaw: "Differential expression of matrix metalloproteinases 2 and 9 by glial Müller cells: response to soluble and extracellular matrix-bound tumor necrosis factor-alpha." in: The American journal of pathology, Vol. 160, Issue 5, pp. 1847-55, (2002) (PubMed).

    Hamacher, Lucas, Lijnen, Buschke, Dunant, Wendel, Grau, Suter, Ricou: "Tumor necrosis factor-alpha and angiostatin are mediators of endothelial cytotoxicity in bronchoalveolar lavages of patients with acute respiratory distress syndrome." in: American journal of respiratory and critical care medicine, Vol. 166, Issue 5, pp. 651-6, (2002) (PubMed).

    Musey, Ding, Cao, Lee, Galloway, Yuen, Jerome, McElrath: "Ontogeny and specificities of mucosal and blood human immunodeficiency virus type 1-specific CD8(+) cytotoxic T lymphocytes." in: Journal of virology, Vol. 77, Issue 1, pp. 291-300, (2002) (PubMed).

    Marfaing-Koka, Maravic, Humbert, Galanaud, Emilie: "Contrasting effects of IL-4, IL-10 and corticosteroids on RANTES production by human monocytes." in: International immunology, Vol. 8, Issue 10, pp. 1587-94, (1997) (PubMed).

    Voorzanger, Touitou, Garcia, Delecluse, Rousset, Joab, Favrot, Blay: "Interleukin (IL)-10 and IL-6 are produced in vivo by non-Hodgkin's lymphoma cells and act as cooperative growth factors." in: Cancer research, Vol. 56, Issue 23, pp. 5499-505, (1997) (PubMed).

    Mey, Hmama, Normier, Revillard: "Alteration of dealcylated lipopolysaccharide antagonistic properties by interaction with plasma factors." in: Journal of leukocyte biology, Vol. 61, Issue 1, pp. 17-23, (1997) (PubMed).

    Ida, Robertson, Voss, Ritz, Anderson: "CD94 ligation induces apoptosis in a subset of IL-2-stimulated NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 5, pp. 2154-60, (1997) (PubMed).

    van Hensbroek, Palmer, Onyiorah, Schneider, Jaffar, Dolan, Memming, Frenkel, Enwere, Bennett, Kwiatkowski, Greenwood: "The effect of a monoclonal antibody to tumor necrosis factor on survival from childhood cerebral malaria." in: The Journal of infectious diseases, Vol. 174, Issue 5, pp. 1091-7, (1996) (PubMed).

    Racadot, Milpied, Bordigoni, Cahn, Plouvier, Lioure, Lutz, Wijdenes, Herve: "Sequential use of three monoclonal antibodies in corticosteroid-resistant acute GVHD: a multicentric pilot study including 15 patients." in: Bone marrow transplantation, Vol. 15, Issue 5, pp. 669-77, (1995) (PubMed).

    Boillot, Capellier, Racadot, Wijdenes, Herve, Barale: "Pilot clinical trial of an anti-TNF alpha monoclonal antibody for the treatment of septic shock." in: Clinical intensive care : international journal of critical & coronary care medicine, Vol. 6, Issue 2, pp. 52-6, (1995) (PubMed).

    Hervé, Flesch, Tiberghien, Wijdenes, Racadot, Bordigoni, Plouvier, Stephan, Bourdeau, Holler: "Phase I-II trial of a monoclonal anti-tumor necrosis factor alpha antibody for the treatment of refractory severe acute graft-versus-host disease." in: Blood, Vol. 79, Issue 12, pp. 3362-8, (1992) (PubMed).

    Hervé, Racadot, Wijdenes, Flesch, Tiberghien, Bordigoni, Holler, Powles, Bourdeau, Wilmer: "Monoclonal anti TNF alpha antibody in the treatment of acute GvHD refractory both to corticosteroids and anti IL-2 R antibody." in: Bone marrow transplantation, Vol. 7 Suppl 2, pp. 149, (1991) (PubMed).

  • 抗原

    TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))

    别名

    TNF alpha

    背景

    TNFa

    途径

    NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, TLR signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Inflammasome
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