FAS 抗体
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- 抗原 See all FAS 抗体
- FAS (TNF Receptor Superfamily, Member 6 (FAS))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This FAS antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS)
- 特异性
- Human/Rat CD95, Mr 45 kDa
- 产品特性
- Mouse Anti-Human CD95-LE/AF
- 内毒素水平
- Low endotoxin
- 免疫原
- Human CD95 transfected L cells
- 克隆位点
- DX3
- 亚型
- IgG2a
- Top Product
- Discover our top product FAS Primary Antibody
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- 应用备注
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- Applications: FC - Quality tested , IHC-PS - Reported in literature , ELISA - Reported in literature
- Working Dilutions: Flow Cytometry Purified (UNLB) antibody 1 g/106 cells FITC, BIOT, PE, APC and SPRD conjugates 10 L/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L
- 说明
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in vivo induction of apoptosis
- 样本量
- 1 mL
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- 0.5 mg of purified immunoglobulin in 1.0 mL of PBS
- 储存液
- Azide free
- 注意事项
- Each reagent is stable for the period shown on the bottle label if stored as directed.
- 储存条件
- -20 °C
- 储存方法
- Aliquot and freeze the low endotoxin, azide-free product at -20 °C immediately upon receipt.
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- 抗原
- FAS (TNF Receptor Superfamily, Member 6 (FAS))
- 别名
- CD95 (FAS 产品)
- 背景
- CD95, also known as Fas and Apo-1, is a 40-50 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. Crosslinking of CD95 by the monoclonal antibodies DX2 and DX3 delivers an apoptotic signal to Fas-sensitive cells, indicating that these monoclonal antibodies recognize a functional epitope of CD95.
- 途径
- p53 Pathway, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
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