FAS 抗体
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北京 101111
Quick Overview for FAS 抗体 (ABIN135817)
抗原
See all FAS 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Mouse Anti-Human CD95-LE/AF
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特异性
- Human/Rhesus/African Green Monkey/Sooty Mangabey CD95, Mr 45 kDa
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产品特性
- Low Endotoxin/Azide Free Anti-Human CD95 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, ELISA, and apoptosis assays.
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内毒素水平
- Low Endotoxin
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免疫原
- Human CD95 transfected L cells
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Phosphate buffered saline, pH 7.4
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储存液
- Azide free
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注意事项
- Each reagent is stable for the period shown on the bottle label if stored as directed.
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储存条件
- 4 °C
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储存方法
- 2-8°C
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- FAS (TNF Receptor Superfamily, Member 6 (FAS))
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别名
- CD95
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背景
- CD95, also known as Fas and Apo-1, is a 40-50 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. Crosslinking of CD95 by the monoclonal antibodies DX2 and DX3 delivers an apoptotic signal to Fas-sensitive cells, indicating that these monoclonal antibodies recognize a functional epitope of CD95.
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基因ID
- 355, 574332, 103216224
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UniProt
- P25445
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途径
- p53 Pathway, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
抗原
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