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BCL2L1 抗体 (AA 3-14)

This anti-BCL2L1 antibody is a 小鼠 单克隆 antibody detecting BCL2L1 in WB. Suitable for 人 和 小鼠.
产品编号 ABIN135025
发货至: 中国

Quick Overview for BCL2L1 抗体 (AA 3-14) (ABIN135025)

抗原

See all BCL2L1 抗体
BCL2L1 (BCL2-Like 1 (BCL2L1))

适用

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人, 小鼠

宿主

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小鼠

克隆类型

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单克隆

标记

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This BCL2L1 antibody is un-conjugated

应用范围

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Western Blotting (WB)

克隆位点

2H12
  • 抗原表位

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    AA 3-14

    特异性

    Mouse/Rat/Human Bcl-xL

    产品特性

    Mouse Anti-Bcl-xL-UNLB

    纯化方法

    Purified

    免疫原

    Bcl-xL peptide (a.a. 3-14) common to mouse and human

    亚型

    IgG2a
  • 应用备注

    • Applications: WB - Quality tested , IP - Reported in literature , FC - Reported in literature , IHC-PS - Reported in literature , ELISA - Reported in literature
    • Working Dilutions: Immunoblotting Purified (UNLB) antibody ≤ 2 g/mL

    样本量

    1 mL

    限制

    仅限研究用
  • 浓度

    0.1 mg/mL

    缓冲液

    0.1 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

    储存液

    Without preservative

    注意事项

    Each reagent is stable for the period shown on the bottle label if stored as directed.

    储存条件

    4 °C

    储存方法

    Store at 2-8°C
  • 抗原

    BCL2L1 (BCL2-Like 1 (BCL2L1))

    别名

    Bcl-xL

    背景

    Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. Bcl-2 and one of its homologues, Bcl-xL, protect cells from apoptosis, while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis. Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2, other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity.

    途径

    Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
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