BCL2L1 抗体 (AA 3-14)
Quick Overview for BCL2L1 抗体 (AA 3-14) (ABIN135025)
抗原
See all BCL2L1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 3-14
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特异性
- Mouse/Rat/Human Bcl-xL
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产品特性
- Mouse Anti-Bcl-xL-UNLB
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纯化方法
- Purified
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免疫原
- Bcl-xL peptide (a.a. 3-14) common to mouse and human
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亚型
- IgG2a
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应用备注
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- Applications: WB - Quality tested , IP - Reported in literature , FC - Reported in literature , IHC-PS - Reported in literature , ELISA - Reported in literature
- Working Dilutions: Immunoblotting Purified (UNLB) antibody ≤ 2 g/mL
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样本量
- 1 mL
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- 0.1 mg of purified immunoglobulin in 1.0 mL of borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added
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储存液
- Without preservative
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注意事项
- Each reagent is stable for the period shown on the bottle label if stored as directed.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C
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- BCL2L1 (BCL2-Like 1 (BCL2L1))
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别名
- Bcl-xL
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背景
- Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. Bcl-2 and one of its homologues, Bcl-xL, protect cells from apoptosis, while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis. Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2, other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity.
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途径
- Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
抗原
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