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- 抗原 See all BCL2L1 抗体
- BCL2L1 (BCL2-Like 1 (BCL2L1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This BCL2L1 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS)
- 特异性
- Human/Mouse/Rat/Rhesus Bcl-xL
- 产品特性
- Mouse Anti-Bcl-xL-UNLB
- 纯化方法
- Purified
- 免疫原
- Recombinant human Bcl-xS
- 克隆位点
- 7B2-5
- 亚型
- IgG3
- Top Product
- Discover our top product BCL2L1 Primary Antibody
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- 应用备注
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- Applications: FC - Quality tested , IHC-PS - Reported in literature , ICC - Reported in literature , WB - Reported in literature , IP - Reported in literature , ELISA - Reported in literature
- Working Dilutions: Flow Cytometry FITC and BIOT conjugates 3 g/106 cells PE conjugate 0.3 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L Immunoblotting Purified (UNLB) antibody 1 g/mL
- 样本量
- 1 mL
- 限制
- 仅限研究用
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- 浓度
- 0.1 mg/mL
- 缓冲液
- 0.1 mg of purified immunoglobulin in 1.0 mL of borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added
- 储存液
- Without preservative
- 注意事项
- Each reagent is stable for the period shown on the bottle label if stored as directed.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C
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The ability of Bcl-x(L) and Bcl-2 to prevent apoptosis can be differentially regulated." in: Cell death and differentiation, Vol. 3, Issue 1, pp. 113-8, (2006) (PubMed).
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The ability of Bcl-x(L) and Bcl-2 to prevent apoptosis can be differentially regulated." in: Cell death and differentiation, Vol. 3, Issue 1, pp. 113-8, (2006) (PubMed).
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- 抗原
- BCL2L1 (BCL2-Like 1 (BCL2L1))
- 别名
- Bcl-xL (BCL2L1 产品)
- 背景
- Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. Bcl-2 and one of its homologues, Bcl-xL, protect cells from apoptosis, while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis. Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2, other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity.
- 途径
- Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
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