Caspase 1 抗体
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北京 101111
Quick Overview for Caspase 1 抗体 (ABIN1305223)
抗原
See all Caspase 1 (CASP1) 抗体适用
宿主
标记
应用范围
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检测范围
- 0.15ng/mL – 10ng/mL
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最低检测浓度
- 100pg/ml
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特异性
- Detects mouse Caspase-1 (p10 and p20 domain). Does not detect human Caspase-1.
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限制
- 仅限研究用
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浓度
- Lot specific
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储存条件
- -20 °C
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- Caspase 1 (CASP1)
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别名
- Caspase-1
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背景
- Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and interleukin-18 (IL-18) and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3/NALP3 responds to a variety of agonists including crystals._x000D_The Caspase-1 (mouse) Matched Pair Detection Set contains all reagents for the development of a sandwich ELISA to measure Caspase-1 (mouse) in cell culture supernatants. This Matched Pair Detection Set is a quantitative alternative to Western blotting to measure inflammasome activation leading to Caspase-1 cleavage and secretion.
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途径
- Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome
抗原
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