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VDAC1 抗体 (Internal Region)

Name: VDAC1 抗体 (Internal Region)
Brand: antibodies-online
SKU: ABIN129654
Availability: OutOfStock

VDAC1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

Western Blot of Rabbit anti-VDAC/Porin antibody.

2 images

(3 references)

产品编号 ABIN129654

发货至: 中国

Datasheet as PDF

抗原 See all VDAC1 抗体

VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))
抗原表位
15

12

7

7

5

4

4

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
Internal Region
适用
90

47

36

5

4

4

3

3

3

3

3

2

2

2

2

1

1

1

1

1
人
宿主
74

24
兔
Compatible Secondaries
克隆类型
64

34
多克隆
标记
45

7

6

5

3

3

3

3

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1
This VDAC1 antibody is un-conjugated
应用范围
77

43

34

19

18

13

13

10

5

5

4

1

1

1

1

1

1

1
Western Blotting (WB), ELISA

特异性

Anti-VDAC/Porin Antibody is directed against human VDAC1/Porin1 protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest that this antibody would react with VDAC1/Porin1 from a wide range or organisms, including avian, mammalian, aquatic and reptilian sources based on 100% homology for the immunogen sequence. Cross reactivity will occur with all forms of VDACs including VDAC1, VDAC2 (4 isoforms) and VDAC3 (2 isoforms). Such broad reactivity makes this antibody useful as an excellent loading control (mitochondrial).

产品特性

VDAC/Porin Antibody recognizes VDAC (also known as Voltage-dependent anion-selective channel protein 1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL) which is an outer membrane mitochondrial protein. The VDAC proteins are ~30-33 kDa (some isoforms are larger - see below). The VDAC proteins are thought to form aqueous channels, or pores, through which adenine nucleotides cross the outer mito-chondrial membrane. VDACs have been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. This complex, formed by VDAC, adenine nucleotide translocator (ANT), and cyclophilin D (CypD), is thought to allow the mitochondria to undergo metabolic uncoupling and irreversible morphologic changes that ultimately destroy the mitochondria during apoptosis. VDACs are highly expressed in heart, liver and skeletal muscle, where concentrations of mitochondria are at their highest. This antibody can be used as a loading control with whole cell lysates and total mitochondrial preparations.

过滤

Sterile filtered

免疫原

VDAC/Porin Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 185-197 of Human VDAC1/Porin1.
Immunogen Type: Peptide

亚型

IgG

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VDAC1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Voltage-Dependent Anion Channel 1 (VDAC1) (AA 1-30), (N-Term) antibody
VDAC1 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB19920 unconjugated

anti-Voltage-Dependent Anion Channel 1 (VDAC1) (N-Term) antibody (APC)
VDAC1 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal APC

anti-Voltage-Dependent Anion Channel 1 (VDAC1) (AA 1-283) antibody
VDAC1 适用: 人 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S152B-23 unconjugated

anti-Voltage-Dependent Anion Channel 1 (VDAC1) (AA 1-283) antibody (HRP)
VDAC1 适用: 人 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S152B-23 HRP

anti-Voltage-Dependent Anion Channel 1 (VDAC1) (N-Term) antibody (HRP)
VDAC1 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal HRP

anti-Voltage-Dependent Anion Channel 1 (VDAC1) (AA 1-283) antibody (FITC)
VDAC1 适用: 人 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S152B-23 FITC

anti-Voltage-Dependent Anion Channel 1 (VDAC1) (N-Term) antibody (Alkaline Phosphatase (AP))
VDAC1 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal Alkaline Phosphatase (AP)

anti-Voltage-Dependent Anion Channel 1 (VDAC1) (AA 1-283) antibody (Biotin)
VDAC1 适用: 人 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S152B-23 Biotin

anti-Voltage-Dependent Anion Channel 1 (VDAC1) (AA 1-283) antibody (PE)
VDAC1 适用: 人 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S152B-23 PE

应用备注

VDAC/Porin Antibody has been tested for use in ELISA and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band at ~30-33 kDa in size corresponding to VDAC/Porin by western blotting in the appropriate cell lysate or extract.

说明

Gene Name: VDAC1

限制

仅限研究用
状态

Liquid

浓度

1.0 mg/mL

缓冲液

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C/-20 °C

储存方法

Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

有效期

12 months
Thakurela, Garding, Jung, Müller, Goebbels, White, Werner, Tiwari: "The transcriptome of mouse central nervous system myelin." in: Scientific reports, Vol. 6, pp. 25828, (2018) (PubMed).

Petermann, Haase, Knebel-Mörsdorf: "Impact of Rac1 and Cdc42 signaling during early herpes simplex virus type 1 infection of keratinocytes." in: Journal of virology, Vol. 83, Issue 19, pp. 9759-72, (2009) (PubMed).

Bourekas, Slivka, Shah, Sunshine, Suarez: "Intraarterial thrombolytic therapy within 3 hours of the onset of stroke." in: Neurosurgery, Vol. 54, Issue 1, pp. 39-44; discussion 44-6, (2003) (PubMed).
抗原

VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))

别名

VDAC/Porin (VDAC1 产品)

别名

vdac1 antibody, VDAC1 antibody, 5076 antibody, ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1 antibody, ATVDAC1 antibody, T22N4.9 antibody, T22N4_9 antibody, voltage dependent anion channel 1 antibody, PORIN antibody, VDAC-1 antibody, AL033343 antibody, Vdac5 antibody, fa13f11 antibody, wu:fa13f11 antibody, zgc:85830 antibody, voltage-dependent anion channel 1 S homeolog antibody, voltage-dependent anion channel 1 antibody, voltage dependent anion channel 1 antibody, vdac1.S antibody, vdac1 antibody, VDAC1 antibody, Vdac1 antibody

背景

VDAC/Porin Antibody recognizes VDAC (also known as Voltage-dependent anion-selective channel protein 1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL) which is an outer membrane mitochondrial protein. The VDAC proteins are ~30-33 kDa (some isoforms are larger - see below). The VDAC proteins are thought to form aqueous channels, or pores, through which adenine nucleotides cross the outer mito-chondrial membrane. VDACs have been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. This complex, formed by VDAC, adenine nucleotide translocator (ANT), and cyclophilin D (CypD), is thought to allow the mitochondria to undergo metabolic uncoupling and irreversible morphologic changes that ultimately destroy the mitochondria during apoptosis. VDACs are highly expressed in heart, liver and skeletal muscle, where concentrations of mitochondria are at their highest. This antibody can be used as a loading control with whole cell lysates and total mitochondrial preparations.

基因ID

130683

UniProt

Q9Y277