PRKACA 抗体 (Catalytic Subunit)
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北京 101111
Quick Overview for PRKACA 抗体 (Catalytic Subunit) (ABIN127012)
抗原
See all PRKACA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Catalytic Subunit
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特异性
- Recognizes a 40 kDa PKA on SDS-PAGE immunoblots
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纯化方法
- Affinity purified
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免疫原
- Synthetic peptide surrounding amino acid 11 of the catalytic subunit of PKA alpha isoform.
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anti-Protein Kinase A, alpha (PRKACA) (Center) antibody
PRKACA 适用: 人, 小鼠 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase A, alpha (PRKACA) (AA 233-351), (Catalytic Subunit) antibodyPRKACA 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase A, alpha (PRKACA) (pThr197) antibodyPRKACA 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase A, alpha (PRKACA) (Internal Region) antibodyPRKACA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase A, alpha (PRKACA) (AA 1-120) antibodyPRKACA 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 1D7 unconjugated
anti-Protein Kinase A, alpha (PRKACA) (AA 1-120) antibodyPRKACA 适用: 人 ELISA 宿主: 小鼠 Monoclonal 7H3A4 unconjugated
anti-Protein Kinase A, alpha (PRKACA) (N-Term) antibodyPRKACA 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase A, alpha (PRKACA) (Thr198) antibodyPRKACA 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase A, alpha (PRKACA) (AA 1-120) antibodyPRKACA 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Kinase A, alpha (PRKACA) (AA 67-94), (N-Term) antibodyPRKACA 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB20762 unconjugated
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应用备注
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Western blot: 0.5-4 μg/mL, Jukat cell lysate can be used as a positive control. Immunoprecipitation: 20-30 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS, pH 7.2, containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C/-80 °C
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储存方法
- Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
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- PRKACA (Protein Kinase A, alpha (PRKACA))
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别名
- PRKACA
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背景
- Protein kinase A (PKA) also known as cAMP-dependent protein kinase, is a 40 kDa protein kinase that phosphorylates serine or threonine residues in target proteins in response to elevated levels of cAMP. The second messenger cAMP is produced in response to a wide variety of hormones & neurotransmitters and regulates cellular processes such as cell growth and differentiation, ion channel conductivity, synaptic release of neurotransmitters & gene transcription. The principle intracellular target for cAMP is PKA. Inactive PKA exists as a tetrameric protein composed of two regulatory (R) subunits and two catalytic (C) subunits. Activation occurs when two cAMP molecules bind to each R subunit which causes a conformational change that releases the active C subunits. Two major PKA isozymes, type I (PKAI) and type II (PKAII) consist of RI and RII respectively, complexed with C. Three different C subunits (alpha, beta, and gamma) and four different R subunits (RI-alpha, RI-beta, RII-alpha, and RII-beta) have been identified. It has been suggested that the complex structure of PKA may be necessary for it to accomplish such diverse functions.Synonyms: PKA C-alpha, cAMP-dependent protein kinase catalytic subunit alpha
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基因ID
- 5566
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NCBI登录号
- NP_002721
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UniProt
- P17612
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途径
- NF-kappaB Signaling, Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals, Lipid Metabolism, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
抗原
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