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CD56 抗体 (Biotin)

NCAM1 适用: 人, Pig FACS 宿主: 小鼠 Monoclonal ERIC-1 Biotin
产品编号 ABIN118741
发货至: 中国
  • 抗原 See all CD56 (NCAM1) 抗体
    CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))
    适用
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    人, Pig
    宿主
    • 148
    • 85
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    小鼠
    克隆类型
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    单克隆
    标记
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    This CD56 antibody is conjugated to Biotin
    应用范围
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    Flow Cytometry (FACS)
    特异性
    Recognizes the (Mr 180, 145, 125 kDa) isoforms of the human neural cell adhesion molecule (NCAM) (1).
    免疫原
    Human retinoblastoma tumor tissue, membrane fraction
    克隆位点
    ERIC-1
    亚型
    IgG1
    Top Product
    Discover our top product NCAM1 Primary Antibody
  • 应用备注
    Studies of neural cell adhesion molecule. May also be used to study isoforms of NCAM expressed on different tumor types. Western blot for analysis of isoforms expressed, did not react with any of the leukemias or lymphomas tested (1). Flow cytometric applications (1 μg to stain 6 x 10e5 cells). Not for use in IHC with formalin-fixed, paraffin embedded sections. The binding of ERIC-1 to both normal and neoplastic tissue is lost when tissues are conventionally fixed in formalin and embedded in paraffin. The epitope was preserved when exposed to dehydrating fixatives such as cold acetone (-20 °C) for 5 minutes.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    100 µg/mL (OD280nm)
    缓冲液
    0.01 M PBS, pH 7.2, containing 2.0 mM EDTA, 1 % BSA as stabilizer and 0.09 % Sodium azide as preservative.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
  • 抗原
    CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))
    别名
    CD56 (NCAM1 产品)
    别名
    CD56 antibody, MSK39 antibody, NCAM antibody, fj56g09 antibody, ncam antibody, ncam1 antibody, wu:fj56g09 antibody, NCAM1 antibody, n-cam antibody, E-NCAM antibody, NCAM-1 antibody, Ncam antibody, Cd56 antibody, N-CAM antibody, N-CAM-1 antibody, NCAM-C antibody, NCAMC antibody, N-CAM-1-B antibody, NCAM-1-B antibody, ncam1-a antibody, ncam1-b antibody, neural cell adhesion molecule 1 antibody, neural cell adhesion molecule 1a antibody, neural cell adhesion molecule 1 S homeolog antibody, neural cell adhesion molecule 1 L homeolog antibody, NCAM1 antibody, ncam1a antibody, ncam1 antibody, LOC100085373 antibody, ncam1.S antibody, Ncam1 antibody, ncam1.L antibody
    背景
    NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig) like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins. NCAM is expressed on most neuroectodermal derived cell lines, tissues and neoplasm such as retinoblastoma, medulloblastoma, astrocytomas and neuroblastoma.Synonyms: N-CAM-1, NCAM, NCAM-1, Neural cell adhesion molecule 1
    基因ID
    4684
    NCBI登录号
    NP_000606
    UniProt
    P13591
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