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HLA-ABC 抗体

This anti-HLA-ABC antibody is a 小鼠 单克隆 antibody detecting HLA-ABC in FACS 和 BR. Suitable for 人. This Primary Antibody has been cited in 4+ publications.
产品编号 ABIN1177256
发货至: 中国

Quick Overview for HLA-ABC 抗体 (ABIN1177256)

抗原

See all HLA-ABC 抗体
HLA-ABC

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This HLA-ABC antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Blocking Reagent (BR)

克隆位点

DX17
  • 品牌

    BD Pharmingen™

    纯化方法

    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

    过滤

    0.2 μm filtered

    内毒素水平

    Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

    免疫原

    Polyclonal Human NK Cell Line

    亚型

    IgG1 kappa
  • 限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1.0 mg/mL

    缓冲液

    No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

    储存液

    Azide free

    储存条件

    4 °C

    储存方法

    Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
  • Gumperz, Litwin, Phillips, Lanier, Parham: "The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor." in: The Journal of experimental medicine, Vol. 181, Issue 3, pp. 1133-44, (1995) (PubMed).

    Lanier, Gumperz, Parham, Melero, López-Botet, Phillips: "The NKB1 and HP-3E4 NK cells receptors are structurally distinct glycoproteins and independently recognize polymorphic HLA-B and HLA-C molecules." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 7, pp. 3320-7, (1995) (PubMed).

    Morton, Kirsch, Nance, Evans, Korman, Strominger: "Orientation of loci within the human major histocompatibility complex by chromosomal in situ hybridization." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 9, pp. 2816-20, (1984) (PubMed).

    Bach, Amos: "Hu-1: Major histocompatibility locus in man." in: Science (New York, N.Y.), Vol. 156, Issue 3781, pp. 1506-8 (PubMed).

  • 抗原

    HLA-ABC

    别名

    HLA-A/B/C

    背景

    The DX17 monoclonal antibody reacts with a monomorphic epitope expressed on all HLA (human leukocyte antigen) class I molecules examined. DX17 immunoprecipitates HLA class I heavy chains (45 kDa) and beta2-microglobulin (12kDa) from radiolabeled human cell lines. HLA is determined by a complex segment of the short arm of chromosome 6 and there are many human HLAs encoded in this segment. The antigenic agglomerate is called MHC, for major histocompatibility complex. Examples of class I loci are HLA-A, -B, and -C, which are serologically assayed, class II loci, e.g., HLA-D/DR and DC1, are tested by lymphocytotoxic methods.

    途径

    TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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