Phospholipase C gamma 2 抗体 (pTyr759) (PE)
(1 reference)-
- 抗原 See all Phospholipase C gamma 2 (PLCG2) 抗体
- Phospholipase C gamma 2 (PLCG2)
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抗原表位
- pTyr759
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适用
- 人, 大鼠, 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Phospholipase C gamma 2 antibody is conjugated to PE
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应用范围
- Intracellular Staining (ICS)
- 品牌
- BD Phosflow™
- 纯化方法
- Purified from tissue culture supernatant or ascites by affinity chromatography
- 免疫原
- Phosphorylated Human PLC-gamma2 Peptide
- 克隆位点
- K86-689-37
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product PLCG2 Primary Antibody
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anti-Phospholipase C gamma 2 (PLCG2) (AA 1-300) antibody
PLCG2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase C gamma 2 (PLCG2) (AA 1-1265) antibodyPLCG2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase C gamma 2 (PLCG2) (AA 1-1265) antibodyPLCG2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase C gamma 2 (PLCG2) (AA 1-1265) antibodyPLCG2 适用: 人 WB, PLA 宿主: 小鼠 Polyclonal unconjugated
anti-Phospholipase C gamma 2 (PLCG2) (pTyr753) antibodyPLCG2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase C gamma 2 (PLCG2) antibodyPLCG2 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Phospholipase C gamma 2 (PLCG2) (pTyr753) antibodyPLCG2 适用: 人 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 3A8B6 unconjugated
anti-Phospholipase C gamma 2 (PLCG2) (AA 826-985) antibodyPLCG2 适用: 人 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 1E10C11 unconjugated
anti-Phospholipase C gamma 2 (PLCG2) (AA 1201-1258) antibodyPLCG2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase C gamma 2 (PLCG2) (AA 930-1152) antibodyPLCG2 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
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- 样本量
- 20 μL
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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: "Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2." in: Molecular and cellular biology, Vol. 24, Issue 22, pp. 9986-99, (2004) (PubMed).
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: "Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2." in: Molecular and cellular biology, Vol. 24, Issue 22, pp. 9986-99, (2004) (PubMed).
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- 抗原
- Phospholipase C gamma 2 (PLCG2)
- 别名
- PLC-gamma 2 (PLCG2 产品)
- 别名
- PLCgamma2 antibody, Plcg-2 antibody, APLAID antibody, FCAS3 antibody, phospholipase C, gamma 2 antibody, phospholipase C gamma 2 antibody, phospholipase C, gamma 2 (phosphatidylinositol-specific) antibody, Plcg2 antibody, PLCG2 antibody
- 背景
- The Phospholipase C (PLC) isozymes hydrolyze phosphatidyl inositol biphosphate to inositol triphosphate and diacylglycerol. The former causes release of calcium from the endoplasmic reticulum, while the latter is an activator of Protein Kinase C. Within the PLC family, PLC-gamma is the only member that contains SH2 and SH3 domains. These domains enable it to interact with protein tyrosine kinases and become enzymatically activated via phosphorylation. It exists as two isoforms: PLC-g1, which is ubiquitously expressed, and PLC-g2, which is found primarily in the hematopoietic system. PLC-g2-null mice exhibit impaired B lymphocyte maturation and defects in Fc receptor functions. Phosphorylation of PLC-g2 at tyrosines 753 and 759 (Y759) is required for activation of PLC-g2 enzyme activity. PLC-g2 phosphorylation at Y759 can be induced by stimulation of the B cell receptor in Ramos cells, the collagen receptor in platelets, and the T cell receptor in Jurkat cells, and it occurs downstream of Btk and BLNK in the signaling cascade of activated B cells. The K86-689.37.73 antibody recognizes PLC-g2 phosphorylated at Y759 in the SH2-SH3 linker region.
- 途径
- RTK signaling, WNT signaling, Fc-epsilon Receptor Signaling Pathway, Inositol Metabolic Process, Myometrial Relaxation and Contraction, Toll-Like Receptors Cascades, VEGF Signaling, BCR Signaling
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