ITK 抗体 (pTyr551) (PE)
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北京 101111
Quick Overview for ITK 抗体 (pTyr551) (PE) (ABIN1177039)
抗原
See all ITK 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pTyr551
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品牌
- BD Phosflow™
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纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Phosphorylated Human Btk Peptide
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亚型
- IgG1 kappa
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anti-IL2-Inducible T-Cell Kinase (ITK) (Internal Region) antibody
Verified ITK 适用: 人, 大鼠 WB, ELISA, IHC, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) antibodyITK 适用: 人 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 5G6 unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) (C-Term) antibodyVerified ITK 适用: 人 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) (AA 2-110) antibodyITK 适用: 人 ELISA 宿主: 小鼠 Monoclonal 5G12C4 unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) (pTyr180) antibodyITK 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) (AA 49-465) antibodyITK 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) antibodyITK 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) (AA 156-190), (N-Term) antibodyITK 适用: 小鼠 WB 宿主: 兔 Polyclonal RB50676 unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) (AA 228-262) antibodyITK 适用: 人 WB 宿主: 兔 Polyclonal RB50773 unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) (AA 169-198) antibodyITK 适用: 人 WB 宿主: 兔 Polyclonal RB03244 unconjugated
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样本量
- 20 μL
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
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- ITK (IL2-Inducible T-Cell Kinase (ITK))
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背景
- Bruton's tyrosine kinase (Btk) is a nonreceptor tyrosine kinase whose function is critical for proper B cell development and signaling. The activity of Btk is regulated by Src mediated phosphorylation of the kinase domain at tyrosine 551 (Y551). This event induces Btk kinase activity and subsequent autophosphorylation at Y223. Phosphorylated Btk then associates with the cell membrane via the interaction of the PH domain with phosphatidylinositol 3, 4, 5-triphosphate. The Tec family kinase Itk plays a critical role in signal transduction downstream of the T cell antigen receptor and has been implicated in the activation of phospholipase C-gamma1 (PLCgamma1), a key regulator of calcium mobilization and extracellular signal-regulated kinase (ERK) activation. Itk is regulated by an activating transphosphorylation event in which Y511 in the kinase domain is phosphorylated by Lck. The 24a/BTK (Y551) monoclonal antibody recognizes the Y551-phosphorylated form of human Btk and the Y511 phosphorylated form of human Itk.
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
抗原
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