(1 reference)-
- 抗原 See all LDLR 抗体
- LDLR (Low Density Lipoprotein Receptor (LDLR))
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抗原表位
- AA 184-195, Extracellular Domain
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LDLR antibody is conjugated to Biotin
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应用范围
- Flow Cytometry (FACS)
- 特异性
- The LDL receptor (160 kDa mature or glycosylated receptor, 120 kDa precursor or unglycosylated receptor) plays a key role in cellular cholesterol homeostasis. The antibody to LDL-R reacts specifically with Human LDL-R and is suitable for use in Flow Cytometry and Immunoblotting. First data show that the antibody does not inhibit binding of LDL. In Immunoblotting, the antibody recognizes the 160 kDa band of LDLR and a 120 kDa band of the LDLR precursor from fibroblasts, hepatocytes, and monocytic cells cultured in the presence of lipoprotein-deficient serum.
- 交叉反应 （详细）
- Species reactivity (tested):Human.
- 纯化方法
- Immunoaffinity chromatography
- 免疫原
- Specific synthetic peptide (sequence not conserved in VLDL receptor and LRP) of the LDL receptor extracellular domain (epitope between residues nos. 184-195, the linker region between repeats 4 and 5).
- Top Product
- Discover our top product LDLR Primary Antibody
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anti-Low Density Lipoprotein Receptor (LDLR) (C-Term) antibody
KO Validated LDLR 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor (LDLR) (AA 22-150) antibodyLDLR 适用: 人 WB, ELISA, FACS, IHC, ICC 宿主: 小鼠 Monoclonal 1B10H10 unconjugated
anti-Low Density Lipoprotein Receptor (LDLR) (AA 781-860) antibodyLDLR 适用: 人, 小鼠, 大鼠, Hamster, 植物 WB, ELISA, FACS, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor (LDLR) antibodyLDLR 适用: 人 ELISA, FACS, IHC, IF 宿主: 兔 Monoclonal 2B10 unconjugated Recombinant Antibody
anti-Low Density Lipoprotein Receptor (LDLR) antibodyLDLR 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor (LDLR) antibodyLDLR 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Low Density Lipoprotein Receptor (LDLR) (AA 497-742) antibodyLDLR 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor (LDLR) (AA 263-509) antibodyLDLR 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor (LDLR) (AA 105-205) antibodyLDLR 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5E7 unconjugated
anti-Low Density Lipoprotein Receptor (LDLR) (AA 335-588) antibodyLDLR 适用: 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Flow cytometry: 1: 10. Receptor binding studies.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with Penicillin / Streptomycin for antibiotic protection
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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: "CD81 expression is important for the permissiveness of Huh7 cell clones for heterogeneous hepatitis C virus infection." in: Journal of virology, Vol. 81, Issue 10, pp. 5036-45, (2007) (PubMed).
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: "CD81 expression is important for the permissiveness of Huh7 cell clones for heterogeneous hepatitis C virus infection." in: Journal of virology, Vol. 81, Issue 10, pp. 5036-45, (2007) (PubMed).
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- 抗原
- LDLR (Low Density Lipoprotein Receptor (LDLR))
- 别名
- LDLR (LDLR 产品)
- 别名
- FH antibody, FHC antibody, LDLCQ2 antibody, Hlb301 antibody, LDLRA antibody, LDLA antibody, LDL receptor-2 antibody, fhc antibody, ldlcq2 antibody, ldlr antibody, ldlr2-a antibody, LDL receptor 1 antibody, ldlr-a antibody, ldlr-b antibody, low density lipoprotein receptor antibody, low density lipoprotein receptor a antibody, low density lipoprotein receptor S homeolog antibody, low density lipoprotein receptor L homeolog antibody, LDLR antibody, Ldlr antibody, ldlra antibody, ldlr.S antibody, ldlr.L antibody
- 背景
- The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.Synonyms: LDL receptor, LDLR, Low-density lipoprotein receptor
- 基因ID
- 3949
- NCBI登录号
- NP_000518
- UniProt
- P01130
- 途径
- Hepatitis C, Lipid Metabolism
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