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- 抗原 See all BACH2 抗体
- BACH2 (BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2))
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抗原表位
- N-Term
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This BACH2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunoprecipitation (IP)
- 特异性
- Bach2 antibody is directed against mouse Bach2 (n-terminus) protein. Anti-Bach-2 was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest 100% homology with Bach2 protein from mouse. Reactivity against homologues from other sources is not known.
- 产品特性
- During an immune response to infectious diseases and cancer, B-cells undergo activation in response to antigen, and differentiate either into short-lived plasma cells, whose numbers contract following withdrawal of the antigenic stimulus, or into memory B-cells. The formation of B-cell memory is the major goal of vaccination, since memory B-cells are able to produce antibodies specific to infections and cancer that can last for the lifetime of the host. Recently it has been shown that the formation of long-lived memory B-cells is dependent upon the transcription factor Bach2, since knockout mice lacking the gene fail to generate class-switched IgG antibody responses and all B-cells undergo default plasma cell differentiation upon antigenic stimulation. While the mechanism by which Bach2 controls B-cell memory fate has been elucidated (it binds and represses the promoter of the gene that encodes the plasma cell master regulatory transcription factor Blimp-1), the upstream mechanism by which the function of Bach2 is regulated is unknown. There is evidence suggesting that Bach2 is phosphorylated in B-cells following stimulation and suspect that this modification may allow the B-cell signaling apparatus to control Bach2 activity and therefore memory fate decisions. Anti-Bach2 is ideal for researchers interested in Cancer and DNA Damage & Repair research.
- 纯化方法
- affinity purified
- 过滤
- Sterile filtered
- 免疫原
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Anti-Bach2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the n-terminus region of the Bach2 protein.
Immunogen Type: Peptide - 亚型
- IgG
- Top Product
- Discover our top product BACH2 Primary Antibody
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anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) (C-Term) antibody
BACH2 适用: 人, 兔, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) (AA 815-841), (C-Term) antibodyBACH2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB21865 unconjugated
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) (AA 136-235) antibodyBACH2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) (Internal Region) antibodyBACH2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) (C-Term) antibodyBACH2 适用: 人, 兔, 豚鼠, 马, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) (N-Term) antibodyBACH2 适用: 小鼠 WB, ELISA, IP 宿主: 兔 Polyclonal unconjugated
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) (Middle Region) antibodyBACH2 适用: 人, 小鼠, 大鼠, 兔, 豚鼠, 马, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Affinity purified Bach-2 antibody has been tested for use in ELISA, Immunoprecipitation, and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 91-140 kDa in size corresponding to Bach2 protein by western blotting in the appropriate cell lysate or extract.
- 说明
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Gene Name: Bach2
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.97 mg/mL
- 缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
- 有效期
- 12 months
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- 抗原
- BACH2 (BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2))
- 别名
- Bach2 (BACH2 产品)
- 别名
- E030004N02Rik antibody, Bach2 antibody, BTBD25 antibody, bach2 antibody, si:dkeyp-4f12.1 antibody, si:dkeyp-4f12.2 antibody, BTB and CNC homology, basic leucine zipper transcription factor 2 antibody, BTB domain and CNC homolog 2 antibody, BTB and CNC homology 1, basic leucine zipper transcription factor 2b antibody, Bach2 antibody, BACH2 antibody, bach2b antibody, bach2 antibody
- 背景
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This antibody is designed, produced, and is suitable for Cancer and DNA Damage & Repair research. During an immune response to infectious diseases and cancer, B-cells undergo activation in response to antigen, and differentiate either into short-lived plasma cells, whose numbers contract following withdrawal of the antigenic stimulus, or into memory B-cells. The formation of B-cell memory is the major goal of vaccination, since memory B-cells are able to produce antibodies specific to infections and cancer that can last for the lifetime of the host. Recently it has been shown that the formation of long-lived memory B-cells is dependent upon the transcription factor Bach2, since knockout mice lacking the gene fail to generate class-switched IgG antibody responses and all B-cells undergo default plasma cell differentiation upon antigenic stimulation. While the mechanism by which Bach2 controls B-cell memory fate has been elucidated (it binds and represses the promoter of the gene that encodes the plasma cell master regulatory transcription factor Blimp-1), the upstream mechanism by which the function of Bach2 is regulated is unknown. There is evidence suggesting that Bach2 is phosphorylated in B-cells following stimulation and suspect that this modification may allow the B-cell signaling apparatus to control Bach2 activity and therefore memory fate decisions. Anti-Bach2 is ideal for researchers interested in Cancer and DNA Damage & Repair research.
Synonyms: BTB and CNC homology 1, basic leucine zipper transcription factor 2 - 基因ID
- 12014
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