IGF1R 抗体 (Chain alpha)
(2 references)-
- 抗原 See all IGF1R 抗体
- IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
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抗原表位
- Chain alpha
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This IGF1R antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func)
- 特异性
- Clone 1H7 recognizes an epitope in the alpha subunits of CD221, demonstrated by Western blotting (Ref.1). Clone 1H7 is reported to partically block binding of IGF-I and IGF-II to CD221 (Ref.1)
- 纯化方法
- Affinity Chromatography on Protein G
- 内毒素水平
- Low Endotoxin
- 克隆位点
- 1H7
- 亚型
- IgG1
- Top Product
- Discover our top product IGF1R Primary Antibody
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anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 251-350) antibody
IGF1R 适用: 人, 小鼠, 大鼠, 犬 FACS 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1346) antibodyIGF1R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1161) antibodyIGF1R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1165), (pTyr1166) antibodyIGF1R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 51-77) antibodyIGF1R 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 1335-1366), (C-Term) antibodyIGF1R 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB01458 unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (C-Term) antibodyIGF1R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 660-760) antibodyIGF1R 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 1101-1367) antibodyIGF1R 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 3G5C1 unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr980) antibodyIGF1R 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Functional Assays. Western blotting. Immunohistochemistry on Paraffin Sections: 1/10-1/40. This product does not requireprotein digestion pre-treatment of paraffin sections. Use pancreas or placenta as histologypositive control tissue. Flow Cytometry Use 10 μL of 1/10 diluted antibody to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS without preservatives or stabilizers
- 储存液
- Without preservative
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
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: "Liposomal doxorubicin-based treatment in a preclinical model of adrenocortical carcinoma." in: The Journal of endocrinology, Vol. 213, Issue 2, pp. 155-61, (2012) (PubMed).
: "Anti insulin-like growth factor I receptor immunoliposomes: a single formulation combining two anticancer treatments with enhanced therapeutic efficiency." in: The Journal of clinical endocrinology and metabolism, Vol. 95, Issue 2, pp. 943-52, (2010) (PubMed).
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: "Liposomal doxorubicin-based treatment in a preclinical model of adrenocortical carcinoma." in: The Journal of endocrinology, Vol. 213, Issue 2, pp. 155-61, (2012) (PubMed).
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- 抗原
- IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
- 别名
- CD221 / IGF1R (IGF1R 产品)
- 背景
- CD221, a 155 kD tyrosine kinase, is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin. The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins.Synonyms: IGF-I receptor, IGF1 Receptor, Insulin-like growth factor 1 receptor
- 基因ID
- 3480
- NCBI登录号
- NP_000866
- UniProt
- P08069
- 途径
- RTK signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy
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