Shigatoxin 1 抗体
适用: E. coli
WB, Func, EIA
宿主: 小鼠
Monoclonal
13C4
unconjugated
-
- 抗原
- Shigatoxin 1
- 适用
- E. coli
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- 非结合性
- 应用范围
- Western Blotting (WB), Functional Studies (Func), Enzyme Immunoassay (EIA)
- 特异性
- The monoclonal antibody 13C4 recognizes the 1B subunit of Shiga-like toxin 1.
- 纯化方法
- Protein G purified
- 克隆位点
- 13C4
- 亚型
- IgG1
-
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
-
- 浓度
- 0.1 mg/mL
- 缓冲液
- PBS, 0.1 % BSA
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 2-8 °C.
-
- 抗原
- Shigatoxin 1
- 物质类
- Chemical
- 背景
- Shiga-like toxins (SLTs), are also called Verotoxins. Enterohemorrhagic Escherichia coli (EHEC) strains which are primarily of serotypes 0157:H7, 026:H11 and O111:H8 have been incriminated as etiologic agents of hemorrhagic colitis and Hemolytic-uremic syndrome, a generalized disease characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. There are several distinct E.coli SLTs. SLT-I and SLT-II are produced by EHEC. SLT-I and Shiga toxin share >99?% deduced amino acid sequence homology, whereas SLT-I and SLT-II share about 60?% deduced amino acid sequence homology. SLT-I and SLT-II are antigenically distinct.The protein structure of the toxin consists of two domains: the A polypeptide that inhibits protein synthesis by targeting ribosomes, and the B polypeptide pentamer that binds to the eukaryotic cell receptor globotriaosylceramide (Gb3) leading to receptor-mediated endocytosis.Synonyms: SLT-1 B subunit, SLT-1b, SLT-Ib, Verocytotoxin 1 subunit B, Verotoxin 1 subunit B, sltB, stxB
- 基因ID
- 916677
- NCBI登录号
- NP_288672
- UniProt
- Q7DH26
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