OLR1 抗体 (Extracellular Domain)
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- 抗原 See all OLR1 抗体
- OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))
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抗原表位
- AA 71-273, Extracellular Domain
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适用
- 人, 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This OLR1 antibody is un-conjugated
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应用范围
- Immunofluorescence (IF), Functional Studies (Func)
- 特异性
- The monoclonal antibody 23C11 recognizes oxidized low-density lipoprotein receptor-1 (LOX-1).
- 交叉反应 （详细）
- Species reactivity (tested):Human, Mouse.
- 纯化方法
- Purified
- 免疫原
- Fusion protein of extracellular domain (aa 71-273) of human LOX-1 with murine Fcgamma1 (LOX-1-muFc) produced in PEAK cells
- 克隆位点
- 23C11
- 亚型
- IgG1
- Top Product
- Discover our top product OLR1 Primary Antibody
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anti-Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1) (AA 201-273) antibody
OLR1 适用: 人, 小鼠, 大鼠, 兔 WB, ELISA, ICC, FACS, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1) (AA 51-314) antibodyOLR1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1) (AA 57-270) antibodyOLR1 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1) (AA 64-92) antibodyOLR1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB21925 unconjugated
anti-Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1) (AA 58-273) antibodyOLR1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1) antibodyOLR1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1) (AA 60-312) antibodyOLR1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1) (AA 81-273) antibodyOLR1 适用: 人 WB, ELISA, ICC, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1) (N-Term) antibodyOLR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1) antibody (APC)OLR1 适用: 人 FACS 宿主: 小鼠 Monoclonal 15C4 APC
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.1 mg/mL
- 缓冲液
- PBS, 0.1 % BSA
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2 - 8 °C.
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- 抗原
- OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))
- 别名
- OLR1 / LOX1 (OLR1 产品)
- 别名
- OLR1 antibody, LOX1 antibody, Olr1 antibody, CLEC8A antibody, LOXIN antibody, SCARE1 antibody, SLOX1 antibody, LOX-1 antibody, SR-EI antibody, Scare1 antibody, Oldlr1 antibody, Oldr1 antibody, PLOX-1 antibody, oxidized low density lipoprotein receptor 1 antibody, oxidized low density lipoprotein (lectin-like) receptor 1 antibody, OLR1 antibody, Olr1 antibody
- 背景
- LOX-1 is a single-pass type II membrane protein (~45 kDa) and belongs to the C-type lectin-like protein superfamily. LOX-1 is expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver, brain aortic intima, bone marrow, spinal cord and substantia nigra. It is also expressed on the surface of dendritic cells. This unique scavenger receptor LOX-1 plays important roles in atherogenesis. LOX-1 mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis, inducing vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. LOX-1 associates with oxLDL inducing the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, LOX-1 acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. LOX-1 is involved in the inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. LOX-1 also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. The LOX-1 gene is a so-called immediate early gene that is dynamically modulated by several factors in vitro and in vivo. LOX-1 expression is induced by stimuli such as inflammatory cytokines, OxLDL, TNF-alpha, TGF-beta, and ANG II in vitro, and several proatherogenic factors in vivo.Synonyms: C-type lectin domain family 8 member A, CLEC8A, LOX-1, Lectin-like oxidized LDL receptor 1, Lectin-type oxidized LDL receptor 1, Ox-LDL receptor 1, Ox-LDL receptor 1 soluble form, Oxidized low-density lipoprotein receptor 1, sLOX-1, sLOX1
- 基因ID
- 4973
- NCBI登录号
- NP_001166103
- UniProt
- P78380
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