HES1 抗体
Quick Overview for HES1 抗体 (ABIN1107520)
抗原
See all HES1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Reacts with Human 30 kDa HES-1 protein. May cross react with Mouse and Rat.
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纯化方法
- Affinity Chromatography on Protein A
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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溶解方式
- Restore in distilled water.
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缓冲液
- 0.1 M Tris, 0.1 M Glycine and 2 % Sucrose, None
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- HES1 (Hes Family bHLH Transcription Factor 1 (HES1))
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别名
- HES1
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背景
- HES1 is a nuclear protein belonging to th basic helix-loop-helix family of transcription factors with a basic helix-loop-helix (bHLH) domain and an Orange domain. The basic domain of HES1 contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. An immediate early response gene to growth factor, HES1 is reported as having a dual function of both transcriptional activator and silencer of acid alpha-glucosidase (GAA), thus contributing to the subtle tissue-specific control of housekeeping genes such as GAA. HES1 a transcriptional repressor of genes which require a bHLH protein for their transcription and also the formation of a complex with a corepressor protein (Groucho) such as TLE2. HES1 may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1.Synonyms: HES-1, HHL, HL, HRY, Hairy and enhancer of split 1, Hairy homolog, Hairy-like
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基因ID
- 3280
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途径
- DNA Damage Repair
抗原
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