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CD180 抗体 (Biotin)

CD180 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal RP-14 Biotin
产品编号 ABIN1105957
发货至: 中国
  • 抗原 See all CD180 抗体
    CD180 (CD180 Molecule (CD180))
    适用
    • 20
    • 9
    • 3
    • 1
    小鼠
    宿主
    • 12
    • 8
    • 2
    大鼠
    克隆类型
    • 12
    • 10
    单克隆
    标记
    • 17
    • 2
    • 2
    • 1
    This CD180 antibody is conjugated to Biotin
    应用范围
    • 12
    • 11
    • 8
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    Flow Cytometry (FACS)
    交叉反应 (详细)
    Species reactivity (tested):Mouse
    纯化方法
    Protein G
    克隆位点
    RP-14
    亚型
    IgG2a
    Top Product
    Discover our top product CD180 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.1 mg/mL
    缓冲液
    PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.
    有效期
    6 months
  • 抗原
    CD180 (CD180 Molecule (CD180))
    别名
    CD180 / RP105 (CD180 产品)
    别名
    Ly78 antibody, CD180 antibody, LY64 antibody, RP105 antibody, F630107B15 antibody, CD180 molecule antibody, CD180 antigen antibody, Cd180 antibody, CD180 antibody
    背景
    Radioprotective 105 (RP105, CD180) is a type 1 transmembrane protein of 105 kDa with extracellular leucine-riche repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. Radioprotective 105 (RP105, CD180) expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (RP/14) cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule B7.2, revealing RP105 as a potent regulator of B-cell activation. RP105 (CD180) has an important role in B-cell activation by LPS. It is important to note that RP105 associates with MD1, which is in this context important for RP105 with respect to B-cell surface expression and LPS recognition and signalling. MD-1 seems to be requisite for efficient expression of RP105.Synonyms: LY64, Lymphocyte antigen 64, Radioprotective 105 kDa protein
    基因ID
    10090
    UniProt
    Q62192
    途径
    Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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