C1QA 抗体
Quick Overview for C1QA 抗体 (ABIN1105606)
抗原
See all C1QA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The monoclonal antibody JL-1 recognizes the collagen-like region (CLR) of Mouse C1q. The monoclonal antibody JL-1 is reactive with the collagen-like region (CLR) only, which is the same region to which autoantibodies in mice and humans are binding. Anti-C1q autoantibodies deposit in glomeruli together with C1q but induce overt renal disease only in the context of glomerular immune complex disease. This provides an explanation why anti-C1q antibodies are especially pathogenic in patients with SLE.
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交叉反应 （详细）
- Species reactivity (tested):Human, Mouse, Rat.
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纯化方法
- Purified
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免疫原
- C1q-/- C57BL/6 mice with Purified Mouse C1q.
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亚型
- IgG2b
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anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 23-245) antibody
C1QA 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 23-167) antibodyC1QA 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 8B5B1 unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 28-245) antibodyC1QA 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 23-167) antibodyC1QA 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 1C7G3 unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 104-237) antibodyC1QA 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal C1QA-2952 unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 104-237) antibodyC1QA 适用: 人 WB, ELISA, Coat 宿主: 小鼠 Monoclonal C1QA-2783 unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 96-245) antibodyC1QA 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 1C9G9 unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 26-125) antibodyC1QA 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 23-245) antibodyC1QA 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 1-245) antibodyC1QA 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % bovine serum albumin
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))
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别名
- C1q A Subunit
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背景
- C1q is a 459 kDa molecule consisting of three individual polypeptide chains. C1q forms together with C1r and C1s the C1 macromolecule, the first component of the classical complement pathway. Interaction of immune complexes with C1q induces a conformational change within the C1 complex, which results in activation of the classical pathway. C1q functions as recognition unit by binding to the heavy chain of IgG or IgM (Fc gamma and Fc micro) provided that the immunoglobulins are bound to their antigen. Furthermore, C1q can also recognize molecular patterns associated with pathogens and it can bind to apoptotic blebs, where it activates the classical complement pathway and mediates phagocytosis. As such, C1q promotes the clearance of apoptotic cells and subsequent exposure of auto antigens, thereby preventing stimulation of the immune system. C1q is predominantly produced by macrophages but also by follicular dendritic cells, interdigitating cells and cells of the monocyte-macrophage lineage. C1q deficiency has a profound effect on host defence and clearance of immune complexes. Absence of C1q may cause autoimmunity by impairment of the clearance of apoptotic cells. Inherited C1q deficiency is also associated with the development of systemic lupus erythematosus (SLE).Synonyms: Complement 1q, Complement C1q, Complement C1q subcomponent subunit A
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基因ID
- 712
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NCBI登录号
- NP_057075
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UniProt
- P02745
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途径
- Complement System
抗原
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