C1QA 抗体 (AA 104-237)
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Quick Overview for C1QA 抗体 (AA 104-237) (ABIN6940765)
抗原
See all C1QA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 104-237
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纯化方法
- Purified by Protein A/G
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免疫原
- Recombinant fragment (around aa 104-237) of human C1QA protein (exact sequence is proprietary)
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亚型
- IgG2b kappa
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应用备注
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Positive Control: Human liver or kidney tissue (IHC).
Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))
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别名
- C1QA
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背景
- C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. C1q deficiency is associated with lupus erythematosus and glomerulonephritis.
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分子量
- 29kDa
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基因ID
- 712
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UniProt
- P02745
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途径
- Complement System
抗原
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