C1QA 抗体
Quick Overview for C1QA 抗体 (ABIN1105605)
抗原
See all C1QA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应 （详细）
- Species reactivity (tested):Mouse
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纯化方法
- Protein G
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亚型
- IgG1
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anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 23-245) antibody
C1QA 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 23-167) antibodyC1QA 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 8B5B1 unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 28-245) antibodyC1QA 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 23-167) antibodyC1QA 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 1C7G3 unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 104-237) antibodyC1QA 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal C1QA-2952 unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 104-237) antibodyC1QA 适用: 人 WB, ELISA, Coat 宿主: 小鼠 Monoclonal C1QA-2783 unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 96-245) antibodyC1QA 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 1C9G9 unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 26-125) antibodyC1QA 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 23-245) antibodyC1QA 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent, A Chain (C1QA) (AA 1-245) antibodyC1QA 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))
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别名
- C1q A Subunit
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背景
- Clq, a member of the 'defense collagen' family, is the first subcomponent of the Cl complex of the classical pathway of complement activation. Several functions have been assigned to the pattern recognition molecule Clq, which include antibody-dependent and independent immune functions like triggering of rapid enhanced phagocytosis resulting in efficient containment of pathogens or clearance of cellular debris, apoptotic cells and immune complexes , and is considered to be mediated by Clq receptors present on the effector cell surface. There remains some uncertainty about the identities of the receptors that mediate Clq functions. Some of the previously described Clq receptor molecules, such as gClqR and cClqR, now appear to have less of a role in Clq functions than in functions unrelated to Clq. Experiments with gene targeted homozygous Clq-deficient mice have suggested a role for Clq in modulation of the humoral immune response, and also in protection against development of autoimmunity. The first component of complement Cl is a complex of three glycoproteins - Clq, Clr, and Cls. Cls and Clr interact to form a Cazf-dependent tetrameric proenzyme complex, C lr,-C 1 s2, which makes contacts with the Clq collagen domain. Binding of Clq to immune complexes (IgG or IgM) via the gClq domain, is considered to induce a conformational change in the collagen region of Clq, which leads to the autoactivation of Clr which, in turn, activates Cls. The activated Cl complex then cleaves components C4 and C2 in the classical complement cascade.Synonyms: Complement 1q, Complement C1q, Complement C1q subcomponent subunit A
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UniProt
- P98086
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途径
- Complement System
抗原
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