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ABCC8 抗体 (AA 1548-1582)

ABCC8 适用: 大鼠 WB, IHC, IF/ICC 宿主: 小鼠 Monoclonal S289-16 unconjugated
产品编号 ABIN1098206
发货至: 中国
  • 抗原 See all ABCC8 抗体
    ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))
    抗原表位
    • 12
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1548-1582
    适用
    • 30
    • 21
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    大鼠
    宿主
    • 24
    • 20
    • 1
    小鼠
    克隆类型
    • 26
    • 19
    单克隆
    标记
    • 22
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ABCC8 antibody is un-conjugated
    应用范围
    • 31
    • 21
    • 15
    • 14
    • 12
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (fixed cells) (IF/ICC)
    原理
    Anti-SUR1 Mouse Monoclonal Antibody
    特异性
    This antibody recognizes human, mouse, and rat SUR1. It does not cross-react with SUR2B.
    交叉反应
    人, 小鼠, 大鼠
    交叉反应 (详细)
    No cross Reactivity with SUR2B
    纯化方法
    Purified by Protein G affinity chromatography.
    免疫原
    Fusion protein corresponding to aa 1548-1582 (cytoplasmic C-terminus) of rat SUR1 (accession no. NP_037171.2).
    克隆位点
    S289-16
    亚型
    IgG1
    Top Product
    Discover our top product ABCC8 Primary Antibody
  • 应用备注
    Immunoblotting: use at 1-2 μg/mL. A band of ~160 kDa is detected.
    Immunohistochemistry: use at 1-10 μg/mL.
    These are recommended concentrations. User should determine optimal concentrations for their application.
    Positive control: Mouse brain membranes.
    限制
    仅限研究用
  • 状态
    Liquid
    溶解方式
    Dilute in PBS or medium which is identical to that used in the assay system.
    浓度
    Lot specific
    缓冲液
    PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    This antibody is stable for at least one (1) year at -20°C.
  • 抗原
    ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))
    别名
    SUR1 (ABCC8 产品)
    别名
    ABC36 antibody, HHF1 antibody, HI antibody, HRINS antibody, MRP8 antibody, PHHI antibody, SUR antibody, SUR1 antibody, SUR1delta2 antibody, TNDM2 antibody, D930031B21Rik antibody, Sur antibody, Sur1 antibody, ATP binding cassette subfamily C member 8 antibody, ATP-binding cassette, sub-family C (CFTR/MRP), member 8 antibody, ABCC8 antibody, Abcc8 antibody
    背景
    ATP-binding cassette sub-family C member 8,Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. {UniProtKB:Q09428}.,Sulfonylurea receptors (SUR) are membrane proteins that are molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the SUR is to sense intracellular levels of ATP and ADP and facilitate the opening or closing of its associatedKir6.x potassium channel, thus monitoring the energy balance within cells.,Cell membrane, Multi-pass membrane protein,Sulfonylurea receptor 1
    NCBI登录号
    NP_037171
    UniProt
    Q09429
    途径
    Negative Regulation of Hormone Secretion
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