TLK1 抗体 (AA 730-755)
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Quick Overview for TLK1 抗体 (AA 730-755) (ABIN107632)
抗原
See all TLK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 730-755
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Supplier Product No.
- 600-401-469
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Supplier
- Rockland
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原理
- Tlk1 Antibody
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交叉反应 （详细）
- This affinity purified antibody is directed against human Tlk-1 protein.
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产品特性
- Synonyms: rabbit anti-TLK1 antibody, TLK-1, TLK 1, PKU-beta antibody, serine threonine protein kinase antibody, Serine/threonine protein kinase tousled like 1 antibody, Tousled like kinase 1 antibody
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纯化方法
- The product was affinity purified from monospecific antiserum by immunoaffinity purification.
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过滤
- Sterile filtered
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免疫原
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Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a C-Terminal region near amino acids 730-755 of human Tlk1 (Tousled-like kinase) (isoform 1) protein.
Immunogen Type: Conjugated Peptide
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亚型
- IgG
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anti-Tousled-Like Kinase 1 (TLK1) (AA 160-230) antibody
TLK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tousled-Like Kinase 1 (TLK1) (AA 111-230) antibodyTLK1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4B3 unconjugated
anti-Tousled-Like Kinase 1 (TLK1) antibodyTLK1 适用: 人 WB, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tousled-Like Kinase 1 (TLK1) (AA 720-750), (C-Term) antibodyTLK1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB3043 unconjugated
anti-Tousled-Like Kinase 1 (TLK1) antibodyTLK1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Tousled-Like Kinase 1 (TLK1) (AA 458-560) antibodyTLK1 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tousled-Like Kinase 1 (TLK1) (C-Term) antibodyTLK1 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Tousled-Like Kinase 1 (TLK1) (AA 730-779) antibodyTLK1 适用: 人, 小鼠 ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tousled-Like Kinase 1 (TLK1) (AA 1-766) antibodyTLK1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Tousled-Like Kinase 1 (TLK1) (AA 251-300) antibodyTLK1 适用: 人, 小鼠, 大鼠, 猴, 犬, 马, 兔, Cow, Pig, 斑马鱼, 豚鼠, Hamster WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Application Note: This affinity purified antibody has been tested for use in ELISA and by western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 86 kDa, 89 kDa or 64 kDa in size corresponding to isoforms of TLk-1 by western blotting in the appropriate cell lysate or extract. This antibody reacts with both phosphorylated and non-phosphorylated forms of Tlk-1 at the S743 residue (isoform 1) of the protein.
Western Blot Dilution: 1:200 - 1:2,000
ELISA Dilution: 1:10,000 - 1:50,000
Other: User Optimized
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.60 mg/mL
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- TLK1 (Tousled-Like Kinase 1 (TLK1))
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别名
- TLK1
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背景
- Background: Tlk-1 (also known as tousled-like kinase, serine/threonine-protein kinase tousled-like 1 and PKU-beta) is a target for Chk1 upon induction of DNA-damage. Tousled-like kinases, first described in Arabadopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly. Tlk-1 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent. Tlk-1 heterodimerizes with Tlk-2. Multiple isoforms of the protein have been detected. Mature Tlk-1 is reported to have an apparent molecular weight of ~86 kDa, ~89 kDa and ~64 kDa corresponding to isoforms 1, 2 and 3 respectively.
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基因ID
- 9874, 33636698
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UniProt
- Q9UKI8
抗原
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