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ISG15 抗体 (AA 2-157) (HRP)

This anti-ISG15 antibody is a 兔 多克隆 antibody detecting ISG15 in ELISA. Suitable for 人.
产品编号 ABIN1046251
发货至: 中国

Quick Overview for ISG15 抗体 (AA 2-157) (HRP) (ABIN1046251)

抗原

See all ISG15 抗体
ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))

适用

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宿主

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克隆类型

  • 50
  • 15
多克隆

标记

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This ISG15 antibody is conjugated to HRP

应用范围

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ELISA
  • 抗原表位

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    AA 2-157

    交叉反应

    纯化方法

    >95%, Protein G purified

    免疫原

    Recombinant Human Ubiquitin-like protein ISG15 protein (2-157AA)

    亚型

    IgG
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    注意事项

    Avoid freeze and thaw cycles.
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))

    别名

    ISG15

    背景

    Background: Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections. Ref.12 Ref.13 Ref.14 Ref.15 Ref.20 Ref.21In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy

    Aliases: G1P2 antibody, hUCRP antibody, IFI 15 antibody, IFI15 antibody, Interferon alpha inducible protein antibody, Interferon induced protein 15 antibody, Interferon induced protein IFI-15K antibody, Interferon stimulated protein 15 kDa antibody, Interferon, alpha-inducible protein (clone IFI-15K) antibody, Interferon-induced 15 kDa protein antibody, Interferon-induced 17 kDa protein antibody, Interferon-induced 17- kDa/15- kDa protein antibody, IP17 antibody, ISG 15 antibody, ISG15 antibody, ISG15 ubiquitin like modifier antibody, ISG15_HUMAN antibody, Ubiquitin cross-reactive protein antibody, Ubiquitin-like protein ISG15 antibody, UCRP antibody

    UniProt

    P05161
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