SLC12A4 抗体 (AA 932-1043)
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- 抗原 See all SLC12A4 抗体
- SLC12A4 (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 4 (SLC12A4))
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抗原表位
- AA 932-1043
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适用
- 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This SLC12A4 antibody is un-conjugated
- 应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (fixed cells) (IF/ICC), Immunoprecipitation (IP)
- 原理
- Anti-K+/Cl-Cotransporter (KCC2) Mouse Monoclonal Antibody
- 特异性
- This antibody recognizes human, mouse and rat KCC2.
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Purified by Protein G affinity chromatography.
- 免疫原
- Fusion protein consisting of aa 932-1043 of rat KCC2 (accession no. NP_599190).
- 克隆位点
- S1-12
- 亚型
- IgG2a
- Top Product
- Discover our top product SLC12A4 Primary Antibody
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anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 4 (SLC12A4) antibody
SLC12A4 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 4 (SLC12A4) (Internal Region) antibodyVerified SLC12A4 适用: 人 ELISA, WB, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 4 (SLC12A4) (AA 601-900) antibodySLC12A4 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 4 (SLC12A4) antibodySLC12A4 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 4 (SLC12A4) (AA 1-110) antibodySLC12A4 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1H6 unconjugated
anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 4 (SLC12A4) (N-Term) antibodySLC12A4 适用: 人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 兔, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 4 (SLC12A4) (N-Term) antibodySLC12A4 适用: 人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 兔, 绵羊 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Immunoblotting: use at 3 μg/mL. A band of ~140 kDa is detected.
Immunohistochemistry: use at 1-5 μg/mL.
Positive control: Adult rat brain
These are recommended concentrations,
Enduser should determine optimal concentrations for their applications. - 限制
- 仅限研究用
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- 状态
- Liquid
- 溶解方式
- Dilute in PBS or medium which is identical to that used in the assay system.
- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- This antibody is stable for at least one (1) year at -20°C.
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- 抗原
- SLC12A4 (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 4 (SLC12A4))
- 别名
- K+/Cl- Cotransporter (SLC12A4 产品)
- 别名
- KCC1 antibody, kcc1 antibody, SLC12A4 antibody, AW546649 antibody, RBCKCC1 antibody, Kcc1 antibody, solute carrier family 12 member 4 antibody, solute carrier family 12 (potassium/chloride transporter), member 4 L homeolog antibody, solute carrier family 12, member 4 antibody, SLC12A4 antibody, slc12a4.L antibody, Slc12a4 antibody
- 背景
- Solute carrier family 12 member 5,Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (PubMed:9930699). Involved in the regulation of dendritic spine formation and maturation (PubMed:22345354). {PubMed:22345354, PubMed:9930699}.,KCC2 is a member of the cation-chloride cotransporter gene family. KCCs lower intracellular chloride concentrations below the electrochemical equilibrium potential. Depending on the concentration gradients of potassium and chloride, KCC2 can operate as a net efflux or influx pathway. KCC2 is expressed at high levels in neurons throughout the nervous system and is localized at inhibitory synapses of the spinal cord. Studies in mice have shown that KCC2 reduces GABA's inhibitory signaling resulting in motor defects, epilepsy, and anxiety-like behavior.,Membrane, Multi-pass membrane protein.,Electroneutral potassium-chloride cotransporter 2, Furosemide-sensitive K-Cl cotransporter, K-Cl cotransporter 2, rKCC2, Neuronal K-Cl cotransporter
- NCBI登录号
- NP_599190
- UniProt
- Q63633
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