Rec.Pr.Thyrosin Phosphate (RPTP) 抗体
适用: 人, Pig, 大鼠
FACS, IF, IP, WB
宿主: 小鼠
Monoclonal
3D7
unconjugated
(1 reference)-
- 抗原
- Rec.Pr.Thyrosin Phosphate (RPTP)
- 适用
- 人, Pig, 大鼠
- 宿主
- 小鼠
- 克隆类型
- 单克隆
- 应用范围
- Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
- 特异性
- Monoclonal antibodies 3G4 and 3D7 have been directed against the extracellular domain of RPTPµ.
- 产品特性
- Cell adhesion
- 纯化方法
- Purified
- 克隆位点
- 3D7
- 亚型
- IgG2a
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- 应用备注
- 3D7 is useful for western blot, immunofluorescence, immunoprecipitation and flow cytometry. Optimal antibody dilution should be determined by titration.
- 说明
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3D7 is a mouse monoclonal IgG2a antibody derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with ExG protein, secreted by NIH-3T3 transfected cells and purified with glutahione beads. The cells have been transfected using a fusion construct, termed ExG, encoding the entire ectodomain of the human RPTPµ molecule (aa 1-742), fused COOH terminally to GST.
- 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.09% sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
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: "Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn)." in: The Journal of biological chemistry, Vol. 275, Issue 15, pp. 11264-9, (2000) (PubMed).
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: "Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn)." in: The Journal of biological chemistry, Vol. 275, Issue 15, pp. 11264-9, (2000) (PubMed).
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- 抗原
- Rec.Pr.Thyrosin Phosphate (RPTP)
- 背景
- Receptor-like protein tyrosine phosphatases (RPTPs) represent a new family of transmembrane proteins that are thought to transduce external signals by dephosphorylating phosphotyrosine residues on intracellular substrates. RPTPµ is a prototypic receptor-like protein-tyrosine phosphatase (RPTP) that mediates homotypic cell-cell interactions. Intracellularly, RPTPµ consists of a relatively large juxtamembrane region (about 150 amino acids) and two conserved phosphatase domains. As in most RPTPs, the first (membrane-proximal) PTP domain of RPTPµ is catalytically active, whereas its second (C-terminal) domain is inactive. RPTPµ is involved in cell-cell adhesion through homophilic interactions and may also play a key role in signal transduction and growth control.
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