CD51 抗体
(3 references)-
- 抗原 See all CD51 (ITGAV) 抗体
- CD51 (ITGAV) (Integrin alpha V (ITGAV))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CD51 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- T-lymphocyte clones NKI-M7 detect a melanoma-associated proteoglycan (MW greater than 450-250 kDa) and a molecular complex, which under reducing conditions consists of 4 compounds of 120, 95, 29 and 25 kDa respectively. NKI-M7 reacts with cultured melanomas melanomas in frozen sections. The antigen detected by NKI-M7 is strongly associated with the adhesion and cytoplasmic spreading of melanoma cells to plastic surfaces and monolayers of vascular endothelial cells. NKI-M7 blocks fibronectin-induced chemotaxic motility and chemokinesis of melanoma cells. In addition to their membrane localization, the antigens detected by NKI-M7are abundant in extracellular adhesion plaques deposited by cultured melanoma cells. NKI-M7 stains primary tumors heterogeneously, whereas metastases are homogeneously stained.
- 产品特性
- CD markers,Cell adhesion
- 纯化方法
- Purified
- 克隆位点
- NKI-M7 (former AMF7)
- 亚型
- IgG1
- Top Product
- Discover our top product ITGAV Primary Antibody
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anti-Integrin alpha V (ITGAV) antibody
ITGAV 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Integrin alpha V (ITGAV) (C-Term) antibodyITGAV 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha V (ITGAV) (AA 560-744) antibodyITGAV 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha V (ITGAV) (AA 775-885) antibodyITGAV 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha V (ITGAV) (AA 51-150) antibodyITGAV 适用: 人, 小鼠 WB, FACS, ELISA, IHC (fro), IHC (p), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha V (ITGAV) antibodyITGAV 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha V (ITGAV) (AA 71-322) antibodyITGAV 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha V (ITGAV) (AA 1-1048) antibodyITGAV 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha V (ITGAV) (AA 1-1048) antibodyITGAV 适用: 人 WB, PLA 宿主: 小鼠 Polyclonal unconjugated
anti-Integrin alpha V (ITGAV) (C-Term) antibodyITGAV 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- NKI-M7 is useful for ELISA, immunoprecipitation, flow cytometry and immunohistochemsitry on frozen sections. Optimal antibody dilution should be determined by titration.
- 说明
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NKI-M7 is a mouse monoclonal IgG2a antibody derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with cultured melanoma cells derived from a human melanoma metastasis.
- 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.09% sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
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: "[Erythema nodosum: a study of 160 cases]." in: Medicina clínica, Vol. 96, Issue 5, pp. 169-72, (1991) (PubMed).
: "Extracellular matrix receptor and platelet antigens on osteoclasts and foreign body giant cells." in: Histochemistry, Vol. 96, Issue 2, pp. 169-76, (1991) (PubMed).
: "Characterization of melanoma-associated surface antigens involved in the adhesion and motility of human melanoma cells." in: International journal of cancer. Journal international du cancer, Vol. 38, Issue 4, pp. 465-73, (1986) (PubMed).
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: "[Erythema nodosum: a study of 160 cases]." in: Medicina clínica, Vol. 96, Issue 5, pp. 169-72, (1991) (PubMed).
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- 抗原
- CD51 (ITGAV) (Integrin alpha V (ITGAV))
- 别名
- vitronectin receptor CD51 (ITGAV 产品)
- 别名
- 1110004F14Rik antibody, 2610028E01Rik antibody, CD51 antibody, D430040G12Rik antibody, MSK8 antibody, VNRA antibody, VTNR antibody, Cd51 antibody, integrin subunit alpha V antibody, integrin alpha V antibody, ITGAV antibody, Itgav antibody
- 背景
- CD51 (Cluster of Differentiation 51), known as vitronectin receptor alpha chain, or integrin alphaV is a type I integral membrane glycoprotein. CD51 forms a heterodimer with integrin beta1 (CD29), beta3 (CD61), beta5, beta6, or beta8. CD51 contains two disulfide-linked subunits of 125 kD and 24 kD. Many extracellular matrix proteins with RGD-motifs are CD51 ligands. In association with its beta chains, CD51 binds vitronectin, von Willebrand factor, fibronectin, thrombospondin, osteopontin, fibrinogen, and laminin. CD51, as an adhesion molecule, plays important roles in leukocytes homing and rolling, mediates bone absorption and angiogenesis. CD51 is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells.
- 途径
- Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Integrin Complex
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