Use your antibodies-online credentials, if available.
Higher expression of GLUT-4 is associated with Oral Epithelial Dysplasia compared to Oral Squamous Cell Carcinoma.
Adipose tissue sirtuin 1 (显示 SIRT1 蛋白) was related to insulin (显示 INS 蛋白) sensitivity. The relationship was still present after controlling for BMI, however, it disappeared after controlling for adipose tissue SLC2A4. Muscle sirtuin 1 (显示 SIRT1 蛋白) was not related to insulin (显示 INS 蛋白) sensitivity.
Results showed that GLUT4 translocation is regulated by TBC1D15 (显示 TBC1D15 蛋白) affecting glucose uptake.
This review will summarize the effects of phytochemicals and their action on insulin (显示 INS 蛋白) signaling pathways accelerating GLUT4 translocation based on the current literature.
Our results demonstrate that IR is associated with high circulating RBP4 (显示 POLR2D 蛋白) and that suppressed RBP4 (显示 POLR2D 蛋白) adipose tissue expression is accompanied by reduced GLUT4 expression in HD. Renal transplantation or HDF (显示 Vcan 蛋白) are effective in lowering serum RBP4 (显示 POLR2D 蛋白) levels.
Cell-autonomous adiposity results from increased cell surface GLUT4 due to ankyrin-B deficiency in humans and mice.
The authors show that insulin (显示 INS 蛋白)-stimulated Glut4-mediated glucose uptake requires PDPK1 (显示 PDPK1 蛋白) phosphorylation of the kinase domain but not mTORC2 (显示 CRTC2 蛋白) phosphorylation of the hydrophobic domain. Nonetheless, an intact hydrophobic domain is required for Glut4-mediated glucose uptake.
Three polymorphisms (rs2654185, rs5415, and rs5417) in SLC2A4 were positively correlated with hip circumference and the rs2654185 locus was also positively associated with thigh circumference. Consumption of n-3 polyunsaturated fatty acids modifies associations between SCD (显示 SCD 蛋白), SLC2A4, and SREBF1 (显示 SREBF1 蛋白) polymorphisms and anthropometric variables and metabolic phenotypes.
increased GLUT4 expression in oral squamous cell carcinoma patients was significantly associated with a poor overall survival (OS, P = 0.035) and recurrence-free survival (RFS, P = 0.001). Furthermore, the ectopic overexpression of GLUT4 in cell lines with low endogenous GLUT4 expression resulted in a significant increase in migratory ability both in vitro and in vivo
The results of the study confirmed the presence of GLUT-1 (显示 SLC2A1 蛋白), GLUT-4 and GLUT-9 proteins in the trophoblast from both, uncomplicated and diabetic pregnancies. In addition, insulin (显示 INS 蛋白) therapy may increase placental expression of GLUT-4 and GLUT-9, and partially GLUT-1 (显示 SLC2A1 蛋白), in women with pregestational and gestational diabetes mellitus.
Feed intake remains low whereas respiratory frequency and body temperature remain higher and expression of HSP90 (显示 HSP90 蛋白), CAT1 (显示 SLC7A1 蛋白), SGLT1 (显示 SLC5A1 蛋白) and GLUT4 increases in some tissues in pigs under chronic heat stress conditions.
TBC1D4 (显示 TBC1D4 蛋白), insulin receptor (显示 INSR 蛋白) and GLUT4 showed altered expression in some tissues in pre-diabetic pigs.
analysis of time- and breed-specific expression patterns of GLUT2 (显示 SLC2A2 蛋白) and GLUT4, which highlight their potential as candidate genes for assessing adipose deposition and muscle development in pigs
Chronic elevated calcium blocks AMPK (显示 PRKAA1 蛋白)-induced GLUT-4 expression in skeletal muscle.
Insulin (显示 INS 蛋白) resistance was associated with a significantly reduced total GLUT4 content in omental adipose tissue, without a change in content in other visceral or subcutaneous adipose sites.
There was a significant difference when pooled means for Glut-4 expression in muscle compared with adipose tissue from different anatomical sites.
Portulaca oleracea L. extract enhanced glucose uptake, which was caused by increased GLUT4 expression at the plasma membrane through activating the PI3K/Akt (显示 AKT1 蛋白) pathway.
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine retains cell surface GLUT4 by suppressing PKC alpha (显示 PKCa 蛋白)-driven endocytic internalization of GLUT4, to enhance glucose uptake into cells and restrict an increase in the blood glucose levels after glucose loading in type 2 Diabetes Mellitus.
The data, therefore, suggest that 1,25(OH)2D3 increases glucose consumption by inducing SIRT1 (显示 SIRT1 蛋白) activation, which in turn increases IRS1 (显示 IRS1 蛋白) phosphorylation and GLUT4 translocation in myotubes.
G4+/- offspring on a High Fat Diet displayed early hypertension associated with increased renal gene expression of renin (显示 REN 蛋白) and the AT1 (显示 SLC33A1 蛋白)- receptors compared to G4+/- on a C diet. This group showed decreased cardiac expression of key genes involved in fatty acid oxidation compared to WT on a C diet.
dynamin (显示 DNM1 蛋白) is a molecular motor (显示 MYO1B 蛋白) which would be involved in GLUT4 translocation by facilitating exocytosis
Insulin (显示 INS 蛋白)-stimulated translocation of GLUT4 and GLUT8 (显示 SLC2A8 蛋白) was down-regulated in the atria of insulin (显示 INS 蛋白) resistance animals, as well as their total protein expression.
The disruption of SM22alpha enhances PDGF-BB-induced GLUT4 translocation and glucose uptake by promoting actin dynamics and cortical actin polymeriza- tion.
Data suggest that Glut4 expression is glucose-dependent in white adipocytes; low glucose availability reduces total NADH/NADPH (显示 FDXR 蛋白) levels; high glucose availability up-regulates total NADH/NADPH (显示 FDXR 蛋白) levels, promotes adipogenesis and lipogenesis, and induces Glut4 expression.
Glucose transporter 4 (GLUT4) is required for myocardial adaptations to exercise, and its absence accelerates heart dysfunction after pressure overload.
Low GLUT1 (显示 SLC2A1 蛋白) and GLUT3 (显示 SLC2A3 蛋白) expression in nonclassical monocytes was unaltered during differentiation into macrophages. GLUT4 mRNA was only detectable in unstimulated macrophages. Neither monocytes nor macrophages were insulin (显示 INS 蛋白) responsive.
Results of the present study suggest that myostatin (显示 MSTN 蛋白) inhibits the expression of GLUT4 mRNA and that the greater ability of double muscled cattle to produce muscle may be due to their greater sensitivity to insulin (显示 INS 蛋白) and greater use of glucose.
GLUT4 gene expression increased during late lactation.
These results suggest that goat GLUT4 functions in the transport of glucose and it may play a positive role in amino acid uptake in mammary glands.
This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM).
, glucose transporter type 4, insulin-responsive
, insulin-responsive glucose transporter type 4
, solute carrier family 2, facilitated glucose transporter member 4
, glucose transporter 4
, glucose transporter type 4
, solute carrier family 2 (facilitated glucose transporter), member 4
, solute carrier family 2, facilitated glucose transporter member 4-like
, Insulin-responsive glucose transporter
, insulin-responsive glucose transporter 4
, insulin-responsive glucose transporter
, Glucose transporter 4 insuline-responsive
, Glucose transporter 4, insuline-responsive
, solute carrier family 2 member 4
, solute carrier family 2 , member 4