Ugr 9-1
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- 应用范围
- Blocking Reagent (BR)
- 序列
- AA sequence: Ile-Ser-Ile-Asp-Pro-Pro-Cys7-Arg-Phe-Cys10 -Tyr-His-Arg-Asp-Gly-Ser-Gly-Asn-Cys19-Val -Tyr-Asp-Ala-Tyr-Gly-Cys26-Gly-Ala-Val-OH Disulfide bonds: Cys7-Cys19, Cys10-Cys26
- 产品特性
- Ugr 9-1 is a blocker of ASIC3 channel
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- 限制
- 仅限研究用
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- 储存条件
- -20 °C
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- 背景
- Ugr9-1 (π-AnmTX Ugr 9a-1) was isolated from the venom of the sea anemone Urticina grebelnyi. Ugr 9-1 reversibly inhibits homomeric human ASIC3. Ugr9-1 fully inhibits transient currents with an IC50 value of around 10 μM and also partially blocks sustained currents (IC50 = 1.4 μM). The peculiarity of this peptide is its ability to block ASIC3 when activated at weak pH ( pH 4.0). Ugr 9-1 does not block or activate ASIC1a, ASIC1b, ASIC2a and Kv1.3 at significant concentrations. Ugr 9-1 significantly reverses inflammatory and acid-induced pain in-vivo in mice. The antinociceptive effect is attributed to the block of the sustained inward Na+ current in sensitive neurons. The mode of action of Ugr 9-1 on ASIC3 is supposedly new compared to that of APETx2 or small organic compounds (sevanol or amiloride).
- 分子量
- 3135 kDa
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