Phrixotoxin-2
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- 应用范围
- Blocking Reagent (BR)
- 序列
- AA sequence: Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp -Glu-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Leu-Val -Cys21-Arg-Leu-Trp-Cys25-Lys-Arg-Ile-Ile-Asn-Met-NH2 Disulfide bonds:Cys2-Cys16, Cys9-Cys21 and Cys15-Cys25
- 产品特性
- Phrixotoxin-2 is a selective blocker of Kv4.2 and Kv4.3 channels
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- 限制
- 仅限研究用
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- 储存条件
- -20 °C
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- 背景
- Phrixotoxin-2 (PaTx2) has been isolated originally from the venom of the Chile fire tarantula Phrixotrichus auratus. Phrixotoxin-2 is a 31 amino acid peptide that contains three disulphide bridges. Phrixotoxin-2 specifically blocks recombinant Kv4.2 and Kv4.3 currents with IC50 values of 34 nM and 71 nM, respectively. It does so by altering the gating properties of the channels. The inhibition of Kv4.2 and Kv4.3 currents is fully reversible upon washout. Kv4.1 is only slightly sensitive to Phrixotoxin-2 (maximal block of 20 by 300 nM). Kv1, Kv2 and Kv3 channel subfamilies are insensitive to this toxin.
- 分子量
- 3921.71 kDa
- CAS-编号
- 221889-63-0
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