BeKm-1
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- 应用范围
- Blocking Reagent (BR)
- 序列
- AA sequence: Arg-Pro-Thr-Asp-Ile-Lys-Cys7-Ser-Glu-Ser -Tyr-Gln-Cys13-Phe-Pro-Val-Cys17-Lys-Ser-Arg -Phe-Gly-Lys-Thr-Asn-Gly-Arg-Cys28-Val-Asn- Gly-Phe-Cys33-Asp-Cys35-Phe-OH Disulfide bonds: Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35
- 产品特性
- BeKm-1 is a selective blocker of hERG1 channel
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- 限制
- 仅限研究用
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- 储存条件
- -20 °C
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- 背景
- BeKm-1 toxin is a peptide toxin that has been isolated from the venom of the Central Asian scorpion Buthus eupeus. BeKm-1 toxin has been reported to be a highly selective inhibitor of the human ether-a-go-go ERG1 channel (hERG1). BeKm-1 inhibits hERG1 channels expressed in HEK-293 cells with an IC50 of 3.3 nM, but has no effect at 100 nM on human EAG, human SK1, rat SK2, human IK, human BK, KCNQ1/KCNE1, KCNQ2/KCNQ3, and KCNQ4 channels. It has also minimal effects on rat ELK1 channel. BeKm-1 inhibits the human ERG1 + KCNE1 combination transiently expressed in HEK-293 cells with an IC50 value in the range of 10 to 30 nM. BeKm-1 toxin preferentially blocks human ERG channel through the closed (resting) state, although some open channel blockade is also reported to occur.
- 分子量
- 4091.70 kDa
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