H-Cys1-Lys-Ser-Hyp-Gly-Ser-Ser-Cys8-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys15-Cys16-Arg-Ser-Cys19-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys26-Tyr-NH2Hyp: hydroxypro line(Disulfide bonds between Cys1-Cys16, Cys8-Cys19 and Cys15-Cys26)
Omega-conotoxin GVIA has been isolated from the venom of the cone Conus eographus. Omega-conotoxin GVIA acts at presynaptic membranes. It binds and blocks specifically Cav2.2 channel with an ED50 of 68pM.