Apicidin
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- 应用范围
- Blocking Antibody (Inhibition)
- 产品特性
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Potent HDAC Inhibitor
Blocks Cell Cycle G1
HIV-1 Promoter
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- 限制
- 仅限研究用
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- 储存条件
- -20 °C
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- 背景
- Potent inhibitor of histone deacetylase (HDAC) activity and proliferation. Induces cell cycle arrest at the G1 phase. At 100 nM it induces a long lasting hyperacetylation of histone H4 while that induced by trichostatin is transient. Stimulates apoptosis. Apoptosis is induced via induction of Fas/Fas ligand. Displays potent antiangiogenic effects and dramatically decreases HIF-1a protein levels and transcriptional activity in human and mouse tumor cell lines. Apicidin is a fungal toxin that has broad spectrum activity against Apicomplexan parasites.
- CAS-编号
- 183506-66-3
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