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SHMT2 encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. 再加上，我们可以发SHMT2 蛋白 (9)和数多这个蛋白质的别的产品。
Showing 10 out of 35 products:
Human Polyclonal SHMT2 Primary Antibody for ICC, IF - ABIN4353390
Kjellin, Johansson, Höög, Lehtiö, Jakobsson, Kjellman: Differentially expressed proteins in malignant and benign adrenocortical tumors. in PLoS ONE 2014
Human Polyclonal SHMT2 Primary Antibody for ICC, IF - ABIN4353389
Kim, Fiske, Birsoy, Freinkman, Kami, Possemato, Chudnovsky, Pacold, Chen, Cantor, Shelton, Gui, Kwon, Ramkissoon, Ligon, Kang, Snuderl, Vander Heiden, Sabatini: SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. in Nature 2015
Data suggest that serine hydroxymethyltransferase 2 (SHMT2) may be a potential target in the treatment of hepatocellular carcinoma (HCC (显示 FAM126A 抗体)).
High SHMT2 expression is associated with idiopathic pulmonary fibrosis.
Site-directed mutagenesis experiments on SHMT1 (显示 SHMT1 抗体) demonstrate that selective enzyme inhibition relies on the presence of a cysteine residue at the active site of SHMT1 (显示 SHMT1 抗体) (Cys204) that is absent in SHMT2.
These results indicate that SHMT2 may be a valuable prognostic biomarker in ER-negative breast cancer cases
our results for the first time showed that miR (显示 MLXIP 抗体)-615-5p prevents proliferation and migration through negatively regulating SHMT2 in HCC (显示 FAM126A 抗体).
The SHMT-2 is the direct targets of miR (显示 MLXIP 抗体)-370 and miR (显示 MLXIP 抗体)-373, respectively, in human articular chondrocytes.
High SHMT2 expression increases glycine-dependent nucleotide synthesis leading to bladder cancer growth.
SHMT2 is required for glioblastoma multiforme cells to adapt to the tumour environment, but also renders these cells sensitive to glycine cleavage system inhibition
SHMT1 (显示 SHMT1 抗体) exists in solution as a tetramer, both in the absence and presence of PLP (显示 PLP1 抗体), while SHMT2 undergoes a dimer-to-tetramer transition.
The present study not only describes individual genetic variation that directly affects SHMT1 (显示 SHMT1 抗体) and SHMT2 activity, but provided insight into the overall regulation of the Folate and Methionine Cycles.
SHMT1 (显示 SHMT1 抗体) and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis
This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants.
serine hydroxymethyltransferase 2 (mitochondrial)
, mitochondrial serine hydroxymethyltransferase
, serine hydroxymethyltransferase, mitochondrial
, GLY A+
, glycine auxotroph A, human complement for hamster
, glycine hydroxymethyltransferase
, serine aldolase
, serine hydroxymethylase
, serine methylase
, threonine aldolase