Use your antibodies-online credentials, if available.
PROC encodes a vitamin K-dependent plasma glycoprotein. 再加上，我们可以发PROC 抗体 (216) 和 PROC 蛋白 (37)和数多这个蛋白质的别的产品。
Showing 10 out of 68 products:
Mouse (Murine) PROC ELISA Kit for Sandwich ELISA - ABIN415711
Kawasaki, Okamoto, Kawasaki, Sata: Thrombomodulin improved liver injury, coagulopathy, and mortality in an experimental heatstroke model in mice. in Anesthesia and analgesia 2014
Human PROC ELISA Kit for Competition ELISA - ABIN612753
Foster, Yoshitake, Davie: The nucleotide sequence of the gene for human protein C. in Proceedings of the National Academy of Sciences of the United States of America 1985
Show all 8 Pubmed References
Data show that activated protein C signals via protease activated receptors PAR2 (显示 F2RL1 ELISA试剂盒)/PAR3 (显示 F2RL2 ELISA试剂盒) to expand Treg cells, mitigating the disease in mice.
insulin (显示 INS ELISA试剂盒) and aPC (显示 APC ELISA试剂盒) converge on a common spliced-X-box binding protein-1 (显示 XBP1 ELISA试剂盒) (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis.
loss of the convertase furin (显示 FURIN ELISA试剂盒) or PC5 (显示 PCSK5 ELISA试剂盒)/6 in hepatocytes results in a approximately 30% decrease in APC (显示 APC ELISA试剂盒) levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (显示 F2 ELISA试剂盒) activation.
APC (显示 APC ELISA试剂盒) modifies pulmonary fibrosis by limiting thrombin (显示 F2 ELISA试剂盒)-dependent macrophage recruitment.
Small interfering RNA-mediated silencing of protein C in apolipoprotein E (显示 APOE ELISA试剂盒)-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis.
These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC (显示 APC ELISA试剂盒)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (显示 APC ELISA试剂盒) in the context of endotoxemia and infection
activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow.
impaired EPCR (显示 PROCR ELISA试剂盒)/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis
SOD prevents thrombomodulin (显示 THBD ELISA试剂盒) methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice.
sPLA2 (显示 PLA2G2A ELISA试剂盒)-V plays a thrombogenic role by impairing the ability of EPCR (显示 PROCR ELISA试剂盒) to promote protein C activation.
Laboratory tests and direct sequencing of PROC and SERPINC1 (显示 SERPINC1 ELISA试剂盒) were conducted for the patient and his family members. Coagulation tests revealed that the patient presented type I antithrombin (显示 SERPINC1 ELISA试剂盒) deficiency combined with decreased protein C activity resulting from a small insertion mutation c.848_849insGATGT in SERPINC1 (显示 SERPINC1 ELISA试剂盒) and a short deletion variant c.572_574delAGA in PROC.
Using protein C-factor VII (显示 TH ELISA试剂盒) chimera demonstrate that APC (显示 APC ELISA试剂盒) light chain amino acid residues outside the EPCR (显示 PROCR ELISA试剂盒)-binding site enable cytoprotective PAR1 signaling.
We recently identified a venous thrombosis patient whose plasma level of protein C antigen is normal, but its anticoagulant activity is only 34 % of the normal level. Genetic analysis revealed that the proband and her younger brother carry a novel heterozygous mutation c.346G>A, p.Gly74Ser (G74S) in PROC.
Developed functional protein S assays that measure both the activated protein C- and TFPI (显示 TFPI ELISA试剂盒)-cofactor activities of protein S in plasma, which are hardly if at all affected by the FV Leiden mutation.
Protein C seems inversely associated with mortality in patients with advanced prostate, lung and pancreatic cancer. Further research should validate protein C as a biomarker for mortality, and explore the effects of protein C on progression of cancer.
Genetically higher protein C was associated with a lower risk of ischaemic heart disease.
EPCR (显示 PROCR ELISA试剂盒) occupancy recruits G-protein coupled receptor kinase 5 (显示 GRK5 ELISA试剂盒), thereby inducing beta-arrestin-2 (显示 ARRB2 ELISA试剂盒) biased PAR1 signaling by both APC (显示 APC ELISA试剂盒) and thrombin (显示 F2 ELISA试剂盒). In
A novel mutation of A309V in PROC was determined in a family of two patients with late onset protein C deficiency
Both probands had hereditary protein C deficiencies, for which their parents were all carriers.
Activated protein c is a ghrelin (显示 GHRL ELISA试剂盒) endopeptidase.
Activated protein C(APC (显示 APC ELISA试剂盒)) combined with protein S(PS) had significant antithrombotic effect. APC (显示 APC ELISA试剂盒) combined with PS prolonged clotting time. Dependence on APC (显示 APC ELISA试剂盒)-cofactor activity of PS for expression of anticoagulant activity by APC (显示 APC ELISA试剂盒).
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
, anticoagulant protein C
, vitamin K-dependent protein C
, protein C (inactivator of coagulation factors Va and VIIIa)
, vitamin K-dependent protein C-like
, autoprothrombin IIA
, blood coagulation factor XIV
, inactivator of coagulation factors Va, VIII
, catalytic region
, protein C (precursor of vitamin K-dependent serine protease)