Ubiquitin-Fold Modifier 1 蛋白 (UFM1)

UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1\; MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M\; MIM 603173) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Dec 2008].. 再加上,我们可以发UFM1 抗体 (12)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
UFM1 51569 P61960
小鼠 UFM1 UFM1 67890 P61961
UFM1 365797 Q5BJP3
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UFM1 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, , ,
Rat (Rattus)

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Human Ubiquitin-Fold Modifier 1 (UFM1) interaction partners

  1. UFM1 His 70 resembles UBA5 (显示 UBA5 蛋白) His336 and enters a negatively charged pocked on the other UFM1 molecule.

  2. These findings explicitly elucidate the role of UBA5 (显示 UBA5 蛋白) dimerization in UFM1 activation.

  3. This study, focused on identifying the mutated gene in patients with hypomyelination with atrophy of the basal ganglia and cerebellum without TUBB4A (显示 TUBB5 蛋白) mutations, revealed a homozygous 3-bp deletion in the UFM1 promoter area, which perfectly segregates with the disease.

  4. Meta analysis identified a new gene, UFM1, that is associated with low von Willebrand factor (显示 VWF 蛋白) levels.

  5. in the absence of UFSP2 (显示 C4orf20 蛋白), a deconjugating enzyme for UFM1, ectopic expression of both UFL1 (显示 UFL1 蛋白) and UFBP1, which serve as the E3-ligase complex for the UFM1-system, dramatically increases UFM1-conjugate formation at the endoplasmic reticulum.

  6. data imply that the combination of a hypomorphic p.Ala371Thr variant in trans with a loss-of-function allele in UBA5 underlies a severe infantile-onset encephalopathy

  7. Biallelic Variants in UBA5 (显示 UBA5 蛋白) Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy

  8. results of an in vitro truncation assay suggest that Uba5 (显示 UBA5 蛋白) residues 57-363 comprise the minimal fragment required for the high-efficiency activation of Ufm1

  9. ASC1 (显示 RPL3 蛋白) is a target for ufmylation and that UFBP1 is an essential component for ASC1 (显示 RPL3 蛋白) ufmylation.

  10. binding of ATP to Uba5 (显示 UBA5 蛋白) approximately Ufm1 thioester was required for efficient transfer of Ufm1 from Uba5 (显示 UBA5 蛋白) to Ufc1 (显示 UFC1 蛋白) via transthiolation.

Mouse (Murine) Ubiquitin-Fold Modifier 1 (UFM1) interaction partners

  1. CNS-specific knockout of Ufm1 in mice causes neonatal death accompanied by microcephaly and apoptosis in specific neurons, further suggesting that the UFM1 system is essential for CNS development and function

  2. High UFM1 expression is associated with Atherosclerosis.

  3. transcription downregulation of the Ufm1 and FAT10 (显示 UBD 蛋白) conjugation system in liver Mallory-Denk bodies formation

  4. These data suggest that UFM1-UFBP1 participate in preventing ER stress-induced apoptosis in protein secretory cells.

  5. A novel type of E3 ligase for the Ufm1 conjugation system.

  6. A novel ubiquitin fold modifier (Ufm1) not been previously associated with ER stress and not found to be induced under any condition was found to be upregulated in the hearts of MCP (显示 CR1L 蛋白) mice (transgenic mice that express MCP-1 (显示 CPT1B 蛋白) specifically in the heart).

  7. loop between beta3 and alpha2 in addition to the C-terminal region of Ufm1 plays a role in binding to UfSP1

蛋白简介UFM1

蛋白简介

UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1\; MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M\; MIM 603173) (Komatsu et al., 2004

Gene names and symbols associated with Ubiquitin-Fold Modifier 1 蛋白 (UFM1)

  • ubiquitin fold modifier 1 (UFM1)
  • ubiquitin-fold modifier 1 (ufm1)
  • ubiquitin-fold modifier (CCP2)
  • ubiquitin fold modifier 1 (ufm1)
  • ubiquitin-fold modifier 1 (Ufm1)
  • ubiquitin-fold modifier 1 L homeolog (ufm1.L)
  • ubiquitin-fold modifier 1 (PR46a)
  • 1810045K17Rik 蛋白
  • AI132708 蛋白
  • AI463323 蛋白
  • bA131P10.1 蛋白
  • BM-002 蛋白
  • C13orf20 蛋白
  • ENSMUSG00000074598 蛋白
  • Gm10726 蛋白
  • RGD1304890 蛋白
  • T32E8.4 蛋白
  • T32E8_4 蛋白
  • ubfm1 蛋白
  • wu:fa10f05 蛋白
  • wu:fb72g01 蛋白
  • zgc:55335 蛋白

Protein level used designations for Ubiquitin-Fold Modifier 1 蛋白 (UFM1)

ubiquitin-fold modifier 1

GENE ID SPECIES
452546 Pan troglodytes
477297 Canis lupus familiaris
549742 Xenopus (Silurana) tropicalis
695866 Macaca mulatta
844107 Arabidopsis thaliana
100528343 Ictalurus punctatus
51569 Homo sapiens
67890 Mus musculus
365797 Rattus norvegicus
530547 Bos taurus
418894 Gallus gallus
100286585 Salmo salar
100172209 Pongo abelii
495839 Xenopus laevis
322756 Danio rerio
5722153 Chlamydomonas reinhardtii
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