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Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. 再加上，我们可以发UGCG 抗体 (38) 和 UGCG 蛋白 (8)和数多这个蛋白质的别的产品。
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Results suggest that the changes of DNA methylation (显示 HELLS ELISA试剂盒) status of the glucosylceramide synthase (GCS) promoter correlates with multidrug resistance in breast cancer.
Glucosylceramide synthase upregulation is associated with sorafenib resistance in hepatocellular carcinoma.
GCS (显示 GCLC ELISA试剂盒) was upregulated in colorectal carcinoma tissues compared to control tissues.
We found upregulation of specific sphingolipid enzymes, namely sphingomyelin synthase 1 (SMS1 (显示 SGMS1 ELISA试剂盒)), sphingomyelinase 3 (SMPD3), and glucosylceramide synthase (GCS) in the endometrium of endometriotic women.
Our data demonstrates a correlation between the expression of the GCS (显示 GCLC ELISA试剂盒) protein and ER-positive/HER-2 (显示 ERBB2 ELISA试剂盒) negative breast cancer
our work indicates that some UGCG polymorphisms are modifying factors in the severity of GD.
GCS (显示 GCLC ELISA试剂盒) was upregulated in PTCs and might be an independent factor affecting prognosis.
Glucosylceramide synthase mRNA were reduced by 62%.
The results thus show that ARF6 (显示 ARF6 ELISA试剂盒) regulates neuronal differentiation through an effect on glucosylceramide synthase and glucosylceramide levels.
DOX could modulate the expression of GCS (显示 GCLC ELISA试剂盒) through the Sp1 (显示 PSG1 ELISA试剂盒) site of GCS (显示 GCLC ELISA试剂盒) promoter in ERalpha (显示 ESR1 ELISA试剂盒)-positive breast cancer cells
we report the development of a novel, orally available glucosylceramide synthase inhibitor (Genz-682452) with pharmacological and safety profiles that have potential for treating Fabry disease.
These results suggest that neuronal glucosylceramide synthase expression modulates mediobasal hypothalamus insulin (显示 INS ELISA试剂盒) signaling and white adipose tissue function in fasted mice.
we measured the expression and activities of Pgp and GCS, UDP-glucose levels, cellular uptake of C12-NBD-ceramide (a fluorescent analogue of ceramide) and ceramide-induced cell death in S and R cells.
Data indicate that verexpression of glucosylceramide synthase in myotubes induces glucosylceramide but enhances insulin (显示 INS ELISA试剂盒) signaling.
Data indicate that mice fed D- threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP), an inhibitor of glucosylceramide synthase and lactosylceramide synthase showed marked reduction in tumor volume.
The present work demonstrates that hypothalamic integration of metabolic signals requires neuronal expression of glucosylceramide synthase (GCS; UDP-glucose:ceramide glucosyltransferase).
Data indicate that mice with cerebroside sulfotransferases (Cst (显示 CORT ELISA试剂盒)) and UDP-glucose:ceramide glucosyltransferase (Ugcg)/Cst (显示 CORT ELISA试剂盒) deficiency had lower ammonium excretion.
glycosphingolipids in hepatocytes are not essential for sterol, glucose, or lipoprotein metabolism. Ugcg inhibitors exert their effect on hepatocytes either independently of GSL (显示 CTSA ELISA试剂盒) or mediated by other (liver) cell types.
Ugcg and Ugt8a (显示 UGT8 ELISA试剂盒) deficient oligodendroglial did not exhibit any phenotypic or myelin structural abnormalities; abundant and structurally intact myelin can form in their absence
Shortly after birth UgcG deficient mice showed dysfunction of cerebellum and peripheral nerves, associated with structural defects
Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. They are present in essentially all animal cells and are believed to have important roles in various cellular processes. UDP-glucose ceramide glucosyltransferase catalyzes the first glycosylation step in glycosphingolipid biosynthesis. The product, glucosylceramide, is the core structure of more than 300 GSLs. UGCG is widely expressed and transcription is upregulated during keratinocyte differentiation.
, UDP-glucose ceramide glucosyltransferase b
, ceramide glucosyltransferase b
, ceramide glucosyltransferase-B
, UDP-glucose:N-acylsphingosine D-glucosyltransferase
, glucosylceramide synthase
, ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 21
, UDP-glucose:ceramide glycosyltransferase