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TRRAP encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. 再加上，我们可以发Transformation/transcription Domain-Associated Protein 试剂盒 (2) 和 和数多这个蛋白质的别的产品。
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Human Monoclonal TRRAP Primary Antibody for ChIP, IP - ABIN2668655
Szutorisz, Canzonetta, Georgiou, Chow, Tora, Dillon: Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage. in Molecular and cellular biology 2005
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Data suggest that ubiquitin thioesterase 7 (HAUSP (显示 USP7 抗体)) may act as an oncogenic protein that can modulate c-MYC (显示 MYC 抗体) protein expression via transformation-transcription domain-associated protein (TRRAP).
study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP (显示 CREBBP 抗体), CBFA2T3 (显示 CBFA2T3 抗体), AMOTL1 (显示 AMOTL1 抗体), FAT4 (显示 FAT4 抗体), FBXO11 (显示 FBXO11 抗体), PLA2G4D (显示 PLA2G4D 抗体), TRRAP and USH2A (显示 USH2A 抗体).
MYC associates with STAGA through extended interactions of the TAD with both TRRAP and GCN5.
Findings establish Trrap as a critical part of the mechanism that restricts differentiation and promotes the maintenance of key features of ESCs (显示 NR2E3 抗体).
TRRAP is targeted for destruction in a cell cycle-dependent fashion.
The over-expression of TRA1 (显示 HSP90B1 抗体) in hepatocirrhosis and hepatocellular carcinoma is correlated with the formation and development of HCC (显示 FAM126A 抗体).
TRRAP harbors a recurrent mutation that clustered in one position (p. Ser722Phe) in 6 out of 167 melanoma samples (approx. 4%). The nature, pattern and functional evaluation of the TRRAP recurrent mutation suggest that TRRAP functions as an oncogene (显示 RAB1A 抗体).
knockdown of the adaptor protein TRRAP significantly increased differentiation of cultured brain tumor-initiating cells, sensitized the cells to apoptotic stimuli, and negatively affected cell cycle progression.
TRRAP binding and the recruitment of histone H3 (显示 HIST3H3 抗体) and H4 acetyltransferase activities are required for the transactivation of a silent TERT (显示 TERT 抗体) gene in exponentially growing human fibroblasts by c-Myc (显示 MYC 抗体) or N-Myc protein (显示 MYCN 抗体).
Data suggest a model in which p53 (显示 TP53 抗体) directly recruits a TRRAP/acetyltransferase complex to the mdm2 (显示 MDM2 抗体) gene to activate transcription. In addition, this study defines a novel mechanism utilized by the p53 tumor suppressor (显示 TP53 抗体) to regulate gene expression.
TRRAP deficiency impairs B-cell development but does not directly affect class switch recombination (CSR (显示 SCARA3 抗体). Instead, cells induced to proliferate undergo apoptosis. Our findings demonstrate a central and general role of TRRAP in cell proliferation.
expression profiles of Trrap-responsive genes, using cDNA microarray in mitotic cells
Data show that the loss of Trrap leads to chromosome missegregation, mitotic exit failure and compromised mitotic checkpoints, which are caused by defective Trrap-mediated transcription of the mitotic checkpoint (显示 BUB3 抗体) proteins Mad1 (显示 MXD1 抗体) and Mad2 (显示 MXI1 抗体).
HAT (显示 HAT 抗体) cofactor Trrap and Tip60 (显示 KAT5 抗体) HAT (显示 HAT 抗体) bind to the chromatin surrounding sites of DNA double-strand breaks (DSBs). Cells may use the same basic mechanism involving HAT (显示 HAT 抗体) complexes to regulate distinct cellular processes, such as transcription and DNA repair.
Fe65 (显示 APBB1 抗体) and its interaction with APP (显示 APP 抗体) play an important role in the response to DNA damage by assisting the recruitment
this study has identified a critical role for Trrap in the mechanism that maintains hematopoietic stem cells and hematopoietic system, and underscores the importance of Trrap and histone modifications in tissue homeostasis.
This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
transformation/transcription domain-associated protein
, transformation/transcription domain-associated protein-like
, 350/400 kDa PCAF-associated factor
, tra1 homolog
, transactivation/transformation-domain associated protein