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The protein encoded by SLC34A2 is a pH-sensitive sodium-dependent phosphate transporter. 再加上，我们可以发SLC34A2 蛋白 (8)和数多这个蛋白质的别的产品。
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A sodium-dependent phosphate transporter gene, NaPi-IIb, was isolated from swine small intestine using cDNA library screening method.
This study validated the role of Npt2b in the pathogenesis of Pulmonary alveolar microlithiasis (PAM (显示 PAM 抗体)).
Overall, our preclinical results suggest that the ADC (显示 ADC 抗体) targeting NaPi2b provides an effective new therapy for the treatment of NSCLC and ovarian cancer and is currently undergoing clinical developments.
NaPi-IIb is the only luminal Na(+) -dependent Pi transporter in the murine ileum and its absence is fully compensated for in adult females by a mechanism involving the bone-kidney axis.
Knockdown of the sodium-dependent phosphate co-transporter 2b (NPT2b) suppresses lung tumorigenesis.
B-RAF (显示 SNRPE 抗体) increases the cell surface protein (显示 CD28 抗体) abundance and activity of the type II Na+-coupled phosphate transporters NaPi-IIa and NaPi-IIb.
that NHERF1 (显示 SLC9A3R2 抗体) associates with NaPi-2b in enterocytes and regulates NaPi-2b adaptation.
Compared with wild-type uremic mice, Npt2b-deficient uremic mice had significantly lower levels of serum phosphate and attenuation of FGF23 (显示 FGF23 抗体).
Npt2b is an important target for the prevention of hyperphosphatemia
In GABARAP (显示 GABARAP 抗体)-deficient mice renal NaPi-IIa is up-regulation and intestinal NaPi-IIb is downregulated.
NaPi-IIb was the predominantly expressed epithelial isoform of the sodium-inorganic phosphate cotransporter and was markedly overexpressed in the proximal region in the infertile knockout compared to the fertile heterozygous c-ros (显示 ROS1 抗体) transgenic mouse
Low SLC34A2 expression is associated with non-small cell lung cancer.
SLC34A2 has an important role in promoting proliferation and tumorigenicity of BC.
SLC34A2 was down-regulated in osteosarcoma patients.SLC34A2 interacted with PTEN (显示 PTEN 抗体), and decreased the phosphorylation of PI3K (显示 PIK3CA 抗体) and AKT (显示 AKT1 抗体), which inactivated the PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体) signaling pathway.
High expression of SLC34A2 was identified in about 2/3 patients and correlated with significantly better patient's overall survival. Epidermal growth factor receptor (显示 EGFR 抗体) mutations were detected in about 53% of patients with no statistically significant difference to patient's overall survival. Anaplastic lymphoma kinase (显示 ALK 抗体) rearrangement was found in 8 out of 175 patients, harboring this abnormality leads to shorter overall survi
we elucidated that miR (显示 MLXIP 抗体)-939 exerted its function mainly through inhibiting SLC34A2/Raf (显示 RAF1 抗体)/MEK (显示 MAP2K1 抗体)/ERK (显示 EPHB2 抗体) pathway, which is activated in GC. Multivariate analysis identified miR (显示 MLXIP 抗体)-939, SLC34A2, and their combination as independent indicators for poor prognosis and tumor recurrence in GC patients.
a novel role of SLC34A2 inbreast cancer stem cells (BCSCs) state regulation and establishes a rationale for targeting the SLC34A2/PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体)/SOX2 (显示 SOX2 抗体) signaling pathway for breast cancer therapy.
Knockdown of SLC34A2 inhibits proliferation.
our work indicated that decreased SLC34A2 expression sensitized BCSCs to doxorubicin via SLC34A2-Bmi1 (显示 BMI1 抗体)-ABCC5 (显示 ABCC5 抗体) signaling and shed new light on understanding the mechanism of chemoresistance in BCSCs. This study not only bridges the missing link between stem cell-related transcription factor (Bmi1 (显示 BMI1 抗体)) and ABC transporter (显示 ABCG2 抗体) (ABCC5 (显示 ABCC5 抗体)) but also contributes to development of potential therapeutics against breast cancer.
Our work sheds new light on the nature of the state of lung cancer stem cell-like cells and the role of SLC34A2 in the tumorigenicity of these cells
SPAK (显示 STK39 抗体) and OSR1 (显示 OXSR1 抗体) are powerful stimulators of the intestinal Na+-coupled phosphate co-transporter NaPi-IIb
The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene.
Na/Pi cotransporter NaPi-IIb
, sodium-dependent phosphate transport protein 2B
, type IIb sodium phosphate cotransporter
, solute carrier family 34 (sodium phosphate), member 2
, sodium-dependent phosphate cotransporter isoform NaPi-IIb
, Na(+)-dependent phosphate cotransporter 2B
, Na(+)/Pi cotransporter 2B
, sodium-phosphate transport protein 2B
, sodium/phosphate cotransporter 2B
, solute carrier family 34 member 2
, type IIb Na/Picotransporter
, type II sodium-dependent phosphate transporter 3b
, rNaPi IIb
, type IIb sodium-phosphate transporter