anti-Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) 抗体

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. 再加上,我们可以发SCNN1A 试剂盒 (12)SCNN1A 蛋白 (9)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
SCNN1A 25122 P37089
SCNN1A 6337 P37088
SCNN1A 20276 Q61180
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Showing 10 out of 281 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
Hamster 非结合性 ICC, IF, IP, IHC, WB ENaC beta, rat kidney tissue. 100 μg 3至4个工作日
$466.70
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Hamster 非结合性 ICC, IF, IHC, WB Immunohistochemistry analysis using Rabbit Anti-ENaC Polyclonal Antibody . Tissue: kidney tissue. Species: Rat. Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:100. Secondary Antibody: FITC Goat Anti-Rabbit (green). Western blot analysis of Rat kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. 100 μg 3至4个工作日
$466.70
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小鼠 非结合性 ICC, IF, IHC, WB ENaC alpha, rat kidney tissue. 100 μg 3至4个工作日
$466.70
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小鼠 FITC ICC, IF, IHC, WB Western blot analysis of Rat kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. Western blot analysis of Mouse kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. 100 μg 3至4个工作日
$517.40
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小鼠 APC ICC, IF, IHC, WB Western blot analysis of Rat kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. Western blot analysis of Mouse kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. 100 μg 3至4个工作日
$526.50
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小鼠 PerCP ICC, IF, IHC, WB Western blot analysis of Rat kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. Western blot analysis of Mouse kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. 100 μg 3至4个工作日
$526.50
详细
小鼠 Atto 655 ICC, IF, IHC, WB Western blot analysis of Rat kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. Western blot analysis of Mouse kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. 100 μg 3至4个工作日
$527.80
详细
小鼠 Atto 488 ICC, IF, IHC, WB Western blot analysis of Rat kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. Western blot analysis of Mouse kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. 100 μg 3至4个工作日
$527.80
详细
小鼠 Atto 594 ICC, IF, IHC, WB Western blot analysis of Rat kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. Western blot analysis of Mouse kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. 100 μg 3至4个工作日
$527.80
详细
小鼠 Atto 700 ICC, IF, IHC, WB Western blot analysis of Rat kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. Western blot analysis of Mouse kidney tissue lysates showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody . Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody  at 1:1000. 100 μg 3至4个工作日
$527.80
详细

引用最多的anti-SCNN1A 抗体

  1. Hamster Polyclonal SCNN1A Primary Antibody for ICC, IF - ABIN863203 : Gu: Effect of [Cl(-)]i on ENaC activity from mouse cortical collecting duct cells. in Journal of cellular physiology 2008 (PubMed)
    Show all 22 Pubmed References

  2. Hamster Polyclonal SCNN1A Primary Antibody for ICC, IF - ABIN863204 : Dyka, May, Enz: Subunits of the epithelial sodium channel family are differentially expressed in the retina of mice with ocular hypertension. in Journal of neurochemistry 2005 (PubMed)
    Show all 22 Pubmed References

  3. Mouse (Murine) Polyclonal SCNN1A Primary Antibody for ICC, IF - ABIN863202 : Jia, Liu, Sun, Kakizoe, Guan, Zhang, Zhou, Yang: mPGES-1-derived PGE2 mediates dehydration natriuresis. in American journal of physiology. Renal physiology 2013 (PubMed)
    Show all 22 Pubmed References

  4. Human Polyclonal SCNN1A Primary Antibody for FACS, ICC - ABIN261466 : Williams, Chamarthi, Goodarzi, Pojoga, Sun, Garza, Raby, Adler, Hopkins, Brown, Jeunemaitre, Ferri, Fang, Leonor, Cui, Guo, Taylor, Ida Chen, Xiang, Raffel, Buchanan, Rotter, Williams, Shi: Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension. in American journal of hypertension 2012 (PubMed)
    Show all 4 Pubmed References

  5. Human Polyclonal SCNN1A Primary Antibody for IF (p), IHC (p) - ABIN682243 : Yamamoto, Hotta, Maeda, Kataoka, Maeda, Hamakawa, Sasaki, Yasui, Asai, Kimura: Mineralocorticoid receptor stimulation induces urinary storage dysfunction via upregulation of epithelial sodium channel expression in the rat urinary bladder epithelium. in Journal of pharmacological sciences 2016 (PubMed)

  6. Human Polyclonal SCNN1A Primary Antibody for ELISA, IHC - ABIN6264945 : Li, Chen, Yang, He, He, Xia, Zhang, Xiang: Single-walled carbon nanohorn aggregates promotes mitochondrial dysfunction-induced apoptosis in hepatoblastoma cells by targeting SIRT3. in International journal of oncology 2018 (PubMed)

更多抗SCNN1A的相互作用对抗体

Human Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) interaction partners

  1. The features described for neutrophils from hypertensive patients could be attributed to alpha-ENaC overexpression.

  2. Here, we present the structure of human ENaC in the uncleaved state determined by single-particle cryo-electron microscopy. The ion channel is composed of a large extracellular domain and a narrow transmembrane domain

  3. Proteolytic cleavage activates epithelial sodium channel (SCNN) by removal of specific segments in finger domains of alpha and gamma subunits. Data suggest that the lower "palm" domain of SCNN1A is essential for allosteric activation of the SCNN heterotetramer [SCNN1A(1)-SCNN1B-SCNN1A(2)-SCNN1G].

  4. In the present study, the SCNN1G gene was associated with 24-h urinary sodium excretion but was not related to blood pressure. The SCNN1A and SCNN1B genes were not associated with blood pressure either.

  5. mutation in the extracellular domain of alphaENaC causes Liddle syndrome by increasing intrinsic channel activity.

  6. The mRNA and alpha-ENaC protein were overexpressed in platelets from hypertensive subjects versus control subjects.

  7. The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells.

  8. Data show that the expression of aquaporin (AQP) 1, AQP3, AQP5, epithelial Na+ channel (ENaC) and sodium potassium ATPase (Na-K-ATPase) are altered in patients with acute respiratory failure (ARF) due to diffuse alveolar damage (DAD), and the cause of DAD does not seem to influence the level of impairment of these channels.

  9. The data indicate that the Lhs1 chaperone selectively recognizes an immature form of alphaENaC, one which has failed to correctly assemble with the other channel subunits via its transmembrane domain.

  10. LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1.

  11. Carriage of the p.W493R-SCNN1A polymorphism has been identified as a risk factor for bronchiectasis, but it is not invariably associated with the phenotype of a hyperactive ENaC channel in the lung.

  12. although subgroup analysis showed alpha-ENaC T663A polymorphism was associated with essential hypertension in North American individuals, these meta-analysis results did not confirm such association overall; conclude that Alpha-ENaC T663A polymorphism might not be a risk factor for essential hypertension

  13. Neither bronchodilatory response nor bicycling time trial performance after salbutamol was affected by genotype at rs2228576.

  14. Four nonsynonymous amino acid variants in SCNN1A in nonwhite Cystic fibrosis patients with non-diagnostic CFTR genotypes was identified.

  15. The rs4149570 and rs7956915 polymorphisms of SCNN1A might play important roles in the susceptibility to respiratory distress syndrome, particularly in term infants.

  16. These results indicate that ENaC functions as a sensor for external Cd2+.

  17. The transcriptional expression of alpha, beta, and gamma subunits of ENaC was elevated in nasal polyp compared to nasal mucosa

  18. The long isoform of alphaENaC forms the structural basis of a channel with different activity and regulation, which may not be easily distinguishable in native tissue, but may underlie sodium hyperabsorption and salt sensitive differences in humans.

  19. ENaC regulates miR-101/miR-199a-3p during embryo implantation with the involvement of CREB phosphorylation.

  20. Five de novo mutations were identified in four genes (SCNN1A, KCNJ16, KCNB2, and KCNT1) in three Brugada syndrome patients

Mouse (Murine) Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) interaction partners

  1. Here, the authors report that the epithelial sodium channel (ENaC) is upregulated and activated in the uterus at labor in mice.

  2. the results of the present study demonstrated that insulin protected the lung epithelium and attenuated pulmonary edema through the upregulation of ENaC via the PI3K/SGK1 pathway in LPSinduced lung injury.

  3. Casein kinase 2 phosphorylation is an important regulator of ENaC activity and sodium handling by the aldosterone sensitive distal nephron.

  4. N-linked glycans on each subunit are required for proper folding, maturation, surface expression, and function of the epithelial sodium channel.

  5. Based on the widespread presence of ENaC along the epididymis we suggest that mutations in ENaC subunits may also be associated with male infertility.

  6. Epithelial sodium channel alpha subunit knpckout (Scnn1a-/-} represses inward Na+ currents in culturedendothelial cell (ECs).

  7. These findings indicate that AMPK promotes the assembly of beta1Pix, 14-3-3 proteins, and Nedd4-2 into a complex that inhibits ENaC by enhancing Nedd4-2 binding to ENaC and its degradation.

  8. Aldosterone promotes increased interaction of NCC and ENaC.

  9. Increased ENAC alpha, beta and gamma subunits expression is associated with Lung disease.

  10. The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells.

  11. ENaC activity is regulated by calpain-2 proteolysis of MARCKS.

  12. nonselective cation channels ( channels consist of at least one alpha-ENaC and one or more acid-sensing ion channel 1a (ASIC1a) proteins.

  13. ENaC and ROMK channel activity in kidney tubules are inhibited in TgWnk4(pseudoaldosteronism type II) mice. Wnk4(PHAII)-induced inhibition of ENaC and ROMK may contribute to the suppression of K(+) secretion in the tubules.

  14. Exosomal GAPDH from Proximal Tubule Cells Regulate ENaC Activity

  15. depletion of Kir4.1 stimulates the expression of ENaCbeta and -gamma subunits in the cortical collecting duct

  16. Lack of epithelial sodium channel-mediated sodium transport along the nephron cannot be compensated for by other sodium channels and/or transporters, only by a high-sodium and reduced-potassium diet.

  17. LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1.

  18. reducing ENaC expression in the connecting tubule induces clear pseudohypoaldosteronism type 1 symptoms during high dietary potassium loading

  19. The findings demonstrated a substantial role of mitochondrial dysfunction in mediating the downregulation of NKCC2 and ENaCalpha in obstructive kidney disease, possibly via iNOS-derived nitric oxide and BNP.

  20. PCSK9(-/-) mice display normal sodium balance and blood pressure regulation despite an increase of cleaved alphaENaC under basal condition

Rabbit Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) interaction partners

  1. mechanical stretch promotes expression

Xenopus laevis Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) interaction partners

  1. epithelial sodium channel activity is modulated by thiols

Guinea Pig Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) interaction partners

  1. Different subunits of ENaC expressed in various cell regions of the cochlea and endolymphatic sac in distinct patterns may form the functional sodium channel to regulate the endolymph and maintain homeostasis in inner ear.

SCNN1A 抗原简介

蛋白简介

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with SCNN1A

  • sodium channel epithelial 1 alpha subunit (Scnn1a) 抗体
  • sodium channel epithelial 1 alpha subunit (SCNN1A) 抗体
  • sodium channel, nonvoltage-gated 1 alpha (Scnn1a) 抗体
  • sodium channel, non voltage gated 1 alpha subunit L homeolog (scnn1a.L) 抗体
  • alphaxENaC 抗体
  • besc2 抗体
  • ENAC 抗体
  • enaca 抗体
  • ENaCalpha 抗体
  • mENaC 抗体
  • SCNEA 抗体
  • scnn1 抗体
  • SCNN1A 抗体

Protein level used designations for SCNN1A

SCNEA , alpha-ENaC , alpha-NaCH , amiloride-sensitive sodium channel subunit alpha , epithelial Na(+) channel subunit alpha , epithelial sodium channel alpha subunit , nonvoltage-gated sodium channel 1 subunit alpha , sodium channel, nonvoltage-gated, type I, alpha , alpha ENaC-2 , amiloride-sensitive epithelial sodium channel alpha subunit , amiloride-sensitive sodium channel subunit alpha 2 , nasal epithelial sodium channel alpha subunit , sodium channel, nonvoltage-gated 1 alpha , ENaC alpha , amiloride-sensitive epithelial sodium channel , sodium channel, nonvoltage-gated, type I, alpha polypeptide , alpha ENaC , epithelial sodium channel ENaC alpha subunit , alpha cENaC 431 , amiloride-sensitve epithelial sodium channel alpha subunit , alpha-subunit renal epithelial sodium channel , epithelium sodium channel alpha subunit , sodium channel, nonvoltage-gated 1, alpha , amiloride-sensitive sodium channel alpha subunit

GENE ID SPECIES
25122 Rattus norvegicus
6337 Homo sapiens
20276 Mus musculus
403650 Canis lupus familiaris
100009488 Oryctolagus cuniculus
397811 Xenopus laevis
282348 Bos taurus
396050 Gallus gallus
396608 Sus scrofa
443488 Ovis aries
451776 Pan troglodytes
100222046 Taeniopygia guttata
100484947 Ailuropoda melanoleuca
100014763 Monodelphis domestica
100135613 Cavia porcellus
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