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SPPL2B encodes a member of the GXGD family of aspartic proteases. 再加上，我们可以发SPPL2B 抗体 (9)和数多这个蛋白质的别的产品。
Showing 4 out of 5 products:
SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER.
TfR1 (显示 TFRC 蛋白) N-terminal fragment is a substrate for intramembrane proteolysis by SPPL2b.
The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2 (显示 ITM2B 蛋白)) determines its processing by signal peptide peptidase-like 2b (SPPL2b).
SPP, SPPL2a (显示 SPPL2A 蛋白), -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis
Results demonstrate that SPPL2b utilizes multiple intramembrane cleavages to liberate the intracellular domain of tumor necrosis factor alpha (显示 TNF 蛋白) into the cytosol.
SPPL2a (显示 SPPL2A 蛋白) and SPPL2b mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 (显示 ITM2B 蛋白) N-terminal fragment.
Alzheimer disease-like mutant SPPL2b slowed intramembrane proteolysis of tumor necrosis factor alpha (显示 TNF 蛋白) and caused a relative increase of longer intracellular cleavage products.
in vivo SPPL2a (显示 SPPL2A 蛋白), but not SPPL2b, exhibit a physiologically relevant contribution to CD74 (显示 CD74 蛋白) proteolysis in B and dendritic cells
This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene.
signal peptide peptidase-like 2B
, signal peptide peptidase-like protein 2
, SPP-like 2B
, protein SPP-like 2B
, protein SPPL2b
, intramembrane protease 4
, presenilin homologous protein 4
, presenilin-like protein 1