Signal Peptide Peptidase-Like 2B 蛋白 (SPPL2B)

SPPL2B encodes a member of the GXGD family of aspartic proteases.

列出全部蛋白 基因 基因ID UniProt
 SPPL2B SPPL2B 56928 Q8TCT7
小鼠 SPPL2B SPPL2B 73218 Q3TD49
大鼠 SPPL2B SPPL2B 362828 Q5PQL3
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Insect Cells 小鼠 rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50至55个工作日
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大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
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大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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更多Signal Peptide Peptidase-Like 2B (SPPL2B)互动伙伴

Zebrafish Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER.

Human Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. TfR1 (显示 TFRC 蛋白) N-terminal fragment is a substrate for intramembrane proteolysis by SPPL2b.

  2. The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2 (显示 ITM2B 蛋白)) determines its processing by signal peptide peptidase-like 2b (SPPL2b).

  3. SPP, SPPL2a (显示 SPPL2A 蛋白), -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

  4. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER.

  5. Results demonstrate that SPPL2b utilizes multiple intramembrane cleavages to liberate the intracellular domain of tumor necrosis factor alpha (显示 TNF 蛋白) into the cytosol.

  6. SPPL2a (显示 SPPL2A 蛋白) and SPPL2b mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 (显示 ITM2B 蛋白) N-terminal fragment.

  7. Alzheimer disease-like mutant SPPL2b slowed intramembrane proteolysis of tumor necrosis factor alpha (显示 TNF 蛋白) and caused a relative increase of longer intracellular cleavage products.

Mouse (Murine) Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. in vivo SPPL2a (显示 SPPL2A 蛋白), but not SPPL2b, exhibit a physiologically relevant contribution to CD74 (显示 CD74 蛋白) proteolysis in B and dendritic cells

蛋白简介SPPL2B

蛋白简介

This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPPL2B

  • signal peptide peptidase-like 2 (sppl2)
  • signal peptide peptidase like 2B (sppl2b)
  • signal peptide peptidase like 2B S homeolog (sppl2b.S)
  • signal peptide peptidase like 2B (SPPL2B)
  • signal peptide peptidase like 2B (Sppl2b)
  • signal peptide peptidase-like 2B (Sppl2b)
  • 3110056O03Rik 蛋白
  • AW550292 蛋白
  • IMP-4 蛋白
  • IMP4 蛋白
  • MGC147524 蛋白
  • PSH4 蛋白
  • PSL1 蛋白
  • RGD1308556 蛋白
  • SPPL2B 蛋白
  • wu:fc16e01 蛋白
  • wu:fc85d12 蛋白
  • zgc:136525 蛋白

Protein level used designations for SPPL2B

signal peptide peptidase-like 2B , signal peptide peptidase-like protein 2 , SPP-like 2B , protein SPP-like 2B , protein SPPL2b , intramembrane protease 4 , presenilin homologous protein 4 , presenilin-like protein 1

GENE ID SPECIES
325540 Danio rerio
780336 Xenopus (Silurana) tropicalis
379574 Xenopus laevis
420056 Gallus gallus
56928 Homo sapiens
73218 Mus musculus
504285 Bos taurus
362828 Rattus norvegicus
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