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SEPHS1 encodes an enzyme that synthesizes selenophosphate from selenide and ATP.
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Arabidopsis thaliana Polyclonal SEPHS1 Primary Antibody for WB - ABIN5706929
Bölter, Sharma, Soll: Localisation of Arabidopsis NDPK2--revisited. in Planta 2007
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Data found that several malignant characteristics of SPS1-deficient F9 cells were reversed, suggesting that SPS1 played a role in supporting and/or sustaining cancer. Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals.
murine and human solanesyl and decaprenyl diphosphate synthases are heterotetramers composed of newly characterized hDPS1 (显示 PDSS1 抗体) (mSPS1 (显示 PDSS1 抗体)) and hDLP1 (显示 PDSS2 抗体) (mDLP1 (显示 PDSS1 抗体))
Data confirm interactions among components of the early steps of the selenocysteine biosynthesis pathway (SEPSECS (显示 SLA 抗体), SECP43 (显示 TRNAU1AP 抗体), SEPHS1, and SEPHS2 (显示 SEPHS2 抗体)); SECP43 (显示 TRNAU1AP 抗体), which interacts with SEPSECS (显示 SLA 抗体) and SEPHS1, is a globular protein that forms oligomers in vivo.
Three SNPs in SEPSECS (显示 SLA 抗体) and SEPHS1 were found to significantly interact with serum selenium level and Crohn's Disease.
Five alternative splice variants of human SPS1 (major type, DeltaE2, DeltaE8, +E9, +E9a) were identified wherein +E9 and +E9a make the same protein.
the Sps1 (显示 SRM 抗体)-encoded enzyme depends on a selenium salvage system that recycles l-selenocysteine, whereas the Sps2 (显示 SEPHS2 抗体) enzyme can function with a selenite assimilation system
Sps1 (显示 SRM 抗体) affect cell viability upon ionizing radiation via modulation of p53 (显示 TP53 抗体) activity. Sps1 (显示 SRM 抗体) and its product selenophosphate might be involved in cancer prevention in a p53 (显示 TP53 抗体)-dependent manner and could be applied to development of a novel cancer therapy.
This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons.
selenide, water dikinase 1
, selenium donor protein 1
, selenophosphate synthase 1
, selenophosphate synthetase 1
, selenide, water dikinase 1-like
, selenophosphate synthetase 1 +E9
, selenophosphate synthetase 1 +E9a
, selenophosphate synthetase 1 delta E2
, selenophosphate synthetase 1 delta E8
, selenophosphate synthetase 1 major
, UDP-glucose-fructose-phosphate glucosyltransferase
, sucrose phosphate synthase
, sucrose-phosphate synthase