anti-SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) 抗体

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. 再加上,我们可以发SETD8 蛋白 (12)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
SETD8 387893 Q9NQR1
SETD8 67956 Q2YDW7
SETD8 689820  
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antibodies-online.cn销售最多的anti-SETD8 抗体

Showing 10 out of 154 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
非结合性 ELISA, IHC, WB ABIN6269524 at 1/100 staining human liver tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. ABIN6269524 at 1/100 staining rat liver tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11至12个工作日
$450.00
详细
非结合性 WB 25 μg 2至3个工作日
$185.00
详细
小鼠 非结合性 EIA, WB 0.4 mL 6至8个工作日
$484.00
详细
非结合性 EIA, WB Western blot analysis of SETD8 antibody (Center) in 293 cell line lysates (35ug/lane). SETD8 (arrow) was detected using the purified Pab. 0.4 mL 6至8个工作日
$484.00
详细
非结合性 EIA, IHC (p), WB 0.4 mL 6至8个工作日
$484.00
详细
非结合性 EIA, WB 0.4 mL 6至8个工作日
$484.00
详细
非结合性 ELISA, IHC, WB Western blot analysis of Hela cell lysate, using SETD8 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277493 at 1/100 staining Mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11至12个工作日
$390.77
详细
非结合性 ELISA, WB Western blot analysis of KMT5A in lysates of 293T, using KMT5A Antibody(ABIN6270371). 100 μL 11至12个工作日
$450.00
详细
小鼠 非结合性 ICC, IF, IHC (p), WB Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-SETD8 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50. 200 μL 11至14个工作日
$484.00
详细
非结合性 WB Western blot analysis of SET07 Antibody in K562 cell line lysates (35ug/lane) 400 μL 2至3个工作日
$515.63
详细

引用最多的anti-SETD8 抗体

  1. Human Monoclonal SETD8 Primary Antibody for ELISA, WB - ABIN533013 : Zhang, Bruice: Product specificity and mechanism of protein lysine methyltransferases: insights from the histone lysine methyltransferase SET8. in Biochemistry 2010 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal SETD8 Primary Antibody for ELISA, WB - ABIN533012 : Houston, McManus, Adams, Sims, Carpenter, Hendzel, Rice: Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stability. in The Journal of biological chemistry 2008 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal SETD8 Primary Antibody for ELISA - ABIN543326 : Nishioka, Rice, Sarma, Erdjument-Bromage, Werner, Wang, Chuikov, Valenzuela, Tempst, Steward, Lis, Allis, Reinberg: PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. in Molecular cell 2002 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal SETD8 Primary Antibody for IHC (p), ELISA - ABIN543325 : Fang, Feng, Ketel, Wang, Cao, Xia, Erdjument-Bromage, Tempst, Simon, Zhang: Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase. in Current biology : CB 2002 (PubMed)
    Show all 2 Pubmed References

更多抗SETD8的相互作用对抗体

Human SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) interaction partners

  1. Furthermore, similar associations were found in the subgroup analysis of race diversity, control design, genotyping methods, and different cancer types... our meta-analysis indicated that the SET8 rs16917496 T/C polymorphism may not play a critical role in cancer development in Asian populations.

  2. Genetic changes in miR-146a and the miR-502 binding site of the SET8 can be effective on the increased risk of breast cancer.

  3. Results suggest that SET domain-containing protein 8 (SET8) may be a key mediator in hyperglycemic memory.

  4. that oncogenic SETD8 was regulated by miR-382 and involved glioma progression

  5. Data found that KMT5A was overexpressed in papillary thyroid carcinoma (PTC) tumors. Its knockdown revealed that KMT5A participated in the proliferation, apoptosis, cell cycle, migration and invasion of PTC cells as well as attenuated fatty acid metabolism. These results provide mounting evidence of KMT5A as an oncogenic mediator in fatty acid metabolism of PTC.

  6. Authors demonstrated that PR-Set7, an epigenetic regulator for H4K20me1 modification, was extensively expressed in the postnatal uteri, and its conditional deletion resulted in a complete lack of endometrial glands and infertility in mice.

  7. MiR-502 medaited histone methyltransferase SET8 expression is associated with outcome of esophageal squamous cell carcinoma.

  8. these date elucidated that NT21MP and miR335 mediated PR of breast cancer cells partly through regulation of Wnt/betacatenin signaling pathway. Activation of miR335 or inactivation of SETD8 could be a novel approach for the treatment of breast cancer.

  9. High expression of SET8 is associated with cervical cancer.

  10. This improves the binding of SAM, SAH, and sinefungin by up to 10,000-fold. A small collection of inhibitors structurally related to SAM were screened and 40 compounds were identified that only inhibit SETD8 when a nucleosome substrate is used

  11. We demonstrated the expression levels of SET8 in TT genotype were higher than in CC genotypes, and high levels of SET8 were associated with poor survival in breast cancer

  12. Lysine methylation represses p53 activity in teratocarcinoma cancer cells via up-regulation of SMYD2 and PR-Set7 and perpetuation of cancer cells proliferation.

  13. The loss of SETD8 concurrently stimulated nucleolar function.

  14. The PPARgamma-SETD8 axis constitutes an epigenetic, p53-independent checkpoint on p21-mediated cellular senescence.

  15. rs16917496 polymorphism may be a risk for predisposition to prostate cancer in an Iranian population.

  16. miR-502/SET8 regulatory circuit emerges as a key regulator of the pathobiology of breast cancer and a focal point for possible therapeutic intervention.

  17. In non-small cell lung cancer cells, SETD8 expression suppression is involved in tumorigenesis and metastasis.

  18. SET8 and ZEB1 are functionally interdependent in promoting the epithelial-mesenchymal transition and enhancing the invasive potential of prostate cancer cells in vitro.

  19. SET8 expression is associated with overall survival in gastric cancer

  20. analysis of a structural model for how Set8 uses multivalent interactions to bind and methylate the nucleosome based on crystallographic and solution studies of the Set8/nucleosome complex

Mouse (Murine) SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) interaction partners

  1. KMT5a was identified as a target gene that was down-regulated in both mRNA and protein level when miR-127-3p mimics were introduced. miR-127-3p regulates the proliferation of myocytes through KMT5a.

  2. Authors demonstrated that PR-Set7, an epigenetic regulator for H4K20me1 modification, was extensively expressed in the postnatal uteri, and its conditional deletion resulted in a complete lack of endometrial glands and infertility in mice.

  3. PR-Set7 is a direct target of Cul4A for degradation and involved in the formation of lung tumors in the conditional Cul4A transgenic mouse model.

  4. These results suggest that Setd8 is an important regulator of erythroid maturation that works in part through repression of Gata2 expression.

  5. These results establish SetD8 as a determinant of erythroid cell maturation and provide a framework for understanding how a broadly expressed histone-modifying enzyme mediates cell-type-specific GATA factor function.

  6. all of the H3K36-specific methyltransferases, including ASH1L, HYPB, NSD1, and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a, and Pr-Set7 were not affected by ubH2A.

  7. Data indicate a vital link between GATA-1 and the histone H4 lysine 20 methyltransferase PR-Set7/SetD8 (SetD8).

  8. Pr-set7 knockdown caused increased gammaH2AX foci on chromosomes indicating DNA damage on chromosomes.

  9. Setd8 is a crucial inhibitor of apoptosis in skin and its activity is essential for epidermal stem cell survival, proliferation and differentiation

  10. the SET8 and PCNA interaction couples H4-K20 methylation with DNA replication

  11. PR-Set7 enzymatic activity is essential for mammalian cell cycle progression and for the maintenance of genomic stability, most likely by monomethylating histone H4K20.

  12. Cell cycle analysis after synchronization indicated that defects at the S and G(2)/M phases were a consequence of decreased H4K20me1 due to the absence of PR-Set7.

  13. Data show that the peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop.

SETD8 抗原简介

蛋白简介

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (By similarity).

Gene names and symbols associated with SETD8

  • lysine methyltransferase 5A (KMT5A) 抗体
  • lysine methyltransferase 5A (Kmt5a) 抗体
  • lysine methyltransferase 5Ab (kmt5ab) 抗体
  • lysine methyltransferase 5A S homeolog (kmt5a.S) 抗体
  • 2410195B05Rik 抗体
  • AA617402 抗体
  • AW536475 抗体
  • kmt5a 抗体
  • kmt5a-a 抗体
  • Pr-set7 抗体
  • RGD1305893 抗体
  • SET07 抗体
  • SET8 抗体
  • setd8 抗体
  • setd8-a 抗体
  • setd8b 抗体
  • wu:fc23f12 抗体
  • zgc:171649 抗体

Protein level used designations for SETD8

H4-K20-HMTase SETD8 , H4-K20-specific histone methyltransferase , H4K20-specific histone methyltransferase splice variant Set8b , N-lysine methyltransferase SETD8 , PR/SET domain containing protein 8 , PR/SET domain-containing protein 07 , PR/SET07 , SET domain-containing protein 8 , histone-lysine N-methyltransferase SETD8 , lysine N-methyltransferase 5A , PR-Set7 , SET domain-containing 8 , SET domain containing (lysine methyltransferase) 8b , SET domain containing 8b , N-lysine methyltransferase KMT5A , SET domain containing (lysine methyltransferase) 8 , histone methyltransferase Pr-set7/Set8 , lysine (K)-specific methyltransferase 5A , Histone-lysine N-methyltransferase KMT5A-A , Lysine-specific methylase 5A-A , N-lysine methyltransferase KMT5A-A , N-lysine methyltransferase SETD8-A , SET domain-containing protein 8-A , histone-lysine N-methyltransferase KMT5A-A , histone-lysine N-methyltransferase SETD8-A , lysine (K)-specific methyltransferase 5A S homeolog , lysine-specific methylase 5A-A

GENE ID SPECIES
387893 Homo sapiens
67956 Mus musculus
532622 Bos taurus
100004770 Danio rerio
689820 Rattus norvegicus
100158384 Xenopus laevis
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