anti-Runt-Related Transcription Factor 2 (RUNX2) 抗体

RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. 再加上,我们可以发RUNX2 试剂盒 (60)RUNX2 蛋白 (12)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
RUNX2 860 Q13950
RUNX2 12393 Q08775
RUNX2 367218  
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antibodies-online.cn销售最多的anti-RUNX2 抗体

Showing 10 out of 253 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-RUNX2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  721_B cell lysate RUNX2 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells WB Suggested Anti-RUNX2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control:.21_B cell lysate  RUNX2 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 EMSA AML-3/Runx2 pAb tested by supershift. Detection of AML-3/Runx2 by EMSA analysis. AML-3/Runx2 pAb was used in a supershift assay (EMSA) with Saos-2 nuclear extract (lane 4). 100 μL Log in to see 1至2个工作日
$495.83
详细
非结合性 WB Observed bind size: 62KD Anti-RUNX2 Picoband antibody,  All lanes: Anti RUNX2  at 0.5ug/ml WB: Recombinant Human RUNX2 Protein 0.5ng Predicted bind size: 50KD Observed bind size: 50KD 100 μg Log in to see 4至6个工作日
$240.00
详细
Cow 非结合性 WB WB Suggested Anti-RUNX2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:2500  Positive Control:  HepG2 cell lysate Sample Type: Lane 1:241 µg mouse mesenchymal stem cell lysate Primary Antibody Dilution: 1:0000Secondary Antibody: Anti-rabbit-HRP Secondary Antibody Dilution: 1:00,000 Color/Signal Descriptions: RUNX2  Gene Name: Anonymous Submitted by: 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 ICC, IF, IHC, IHC (p), WB Western Blot: RUNX2 Antibody [NBP1-89104] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp Immunocytochemistry/Immunofluorescence: RUNX2 Antibody [NBP1-89104] - Staining of human cell line U-2 OS shows positivity in nuclei but not nucleoli. 0.1 mL Log in to see 10至13个工作日
$491.63
详细
非结合性 WB Anti-RUNX2 antibody, Western blotting Lane 1: Rat Thymus Tissue Lysate Lane 2: Rat Testis Tissue Lysate 100 μg Log in to see 4至6个工作日
$240.00
详细
Cow 非结合性 WB WB Suggested Anti-RUNX2 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:1562500  Positive Control:  Jurkat cell lysate Host:  Rabbit  Target Name:  RUNX2  Sample Tissue:  Human Jurkat  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2至3个工作日
$229.00
详细
Cow 非结合性 WB WB Suggested Anti-Runx2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Rat Liver 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 DB Dot blot analysis of anti-Phospho-RUNX2-S533 Antibody (ABIN389942) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Log in to see 10至11个工作日
$335.50
详细
Cow 非结合性 WB WB Suggested Anti-RUNX2 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate 100 μL Log in to see 2至3个工作日
$229.00
详细

引用最多的anti-RUNX2 抗体

  1. Human Polyclonal RUNX2 Primary Antibody for DB - ABIN389942 : McNamara, Sjöström, Burgess, Kim, Liu, Gordonov, Moghe, Meek, Oreffo, Su, Dalby: Skeletal stem cell physiology on functionally distinct titania nanotopographies. in Biomaterials 2011 (PubMed)
    Show all 8 Pubmed References

  2. Human Polyclonal RUNX2 Primary Antibody for WB - ABIN3043708 : Li, Chen, Peng, Zhou, Fang: Pulsed electromagnetic fields protect the balance between adipogenesis and osteogenesis on steroid-induced osteonecrosis of femoral head at the pre-collapse stage in rats. in Bioelectromagnetics 2014 (PubMed)
    Show all 6 Pubmed References

  3. Human Polyclonal RUNX2 Primary Antibody for WB - ABIN3043428 : Wang, Mu, Fan, Yu, Yan, Lei, Tang, Wang, Zheng, Yu, Zhang: Insulin-like growth factor 1 can promote the osteogenic differentiation and osteogenesis of stem cells from apical papilla. in Stem cell research 2012 (PubMed)
    Show all 6 Pubmed References

  4. Human Polyclonal RUNX2 Primary Antibody for EMSA - ABIN3434043 : Huang, Xie, Konaka, Sodek, Zhau, Chung: Human osteocalcin and bone sialoprotein mediating osteomimicry of prostate cancer cells: role of cAMP-dependent protein kinase A signaling pathway. in Cancer research 2005 (PubMed)
    Show all 5 Pubmed References

  5. Human Polyclonal RUNX2 Primary Antibody for ICC, IF - ABIN4351437 : Mao, Shin, Mooney: Effects of substrate stiffness and cell-cell contact on mesenchymal stem cell differentiation. in Biomaterials 2016 (PubMed)
    Show all 5 Pubmed References

  6. Human Monoclonal RUNX2 Primary Antibody for IF, IHC (p) - ABIN514045 : Wang, Li, Li, Yang, Sasaki, Wang, Zhou, Araki, Mezawa, Takai, Ogata: Effects of inorganic polyphosphate on bone sialoprotein gene expression. in Gene 2010 (PubMed)
    Show all 5 Pubmed References

  7. Human Polyclonal RUNX2 Primary Antibody for ICC, IF - ABIN4351441 : Martínez-Abadías, Holmes, Pankratz, Wang, Zhou, Jabs, Richtsmeier: From shape to cells: mouse models reveal mechanisms altering palate development in Apert syndrome. in Disease models & mechanisms 2013 (PubMed)
    Show all 3 Pubmed References

  8. Human Polyclonal RUNX2 Primary Antibody for ICC, IF - ABIN4351459 : Mao, Shin, Utech, Wang, Uzun, Li, Cooper, Hu, Zhang, Weitz, Mooney: Deterministic encapsulation of single cells in thin tunable microgels for niche modelling and therapeutic delivery. in Nature materials 2016 (PubMed)
    Show all 2 Pubmed References

  9. Human Monoclonal RUNX2 Primary Antibody for IF, IHC (p) - ABIN560185 : Sase, Suzuki, Miura, Shiiba, Sato, Nakamura, Takagi, Onodera, Miki, Watanabe, Ishida, Ohnuma, Sasaki, Sato, Karasawa, Shibata, Unno, Sasaki, Sasano: Runt-related transcription factor 2 in human colon carcinoma: a potent prognostic factor associated with estrogen receptor. in International journal of cancer. Journal international du cancer 2012 (PubMed)
    Show all 2 Pubmed References

  10. Cow (Bovine) Polyclonal RUNX2 Primary Antibody for WB - ABIN2780588 : Lee, Lee, Ryoo, Park, Park, Bae, Cho, Park: The odontogenic ameloblast-associated protein (ODAM) cooperates with RUNX2 and modulates enamel mineralization via regulation of MMP-20. in Journal of cellular biochemistry 2010 (PubMed)
    Show all 2 Pubmed References

更多抗RUNX2的相互作用对抗体

Human Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Knockdown of RUNX2 significantly inhibited TE-1 and EC-109 cell viability, repressed TE-1 cell migration and invasion, and increased TE-1 cell apoptosis and were associated with the activation of the PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体) and ERK (显示 EPHB2 抗体) pathways.

  2. Results show that RUNX2 gene silencing increased gemcitabine (GEM (显示 GEM 抗体)) sensitivity of p53mutated pancreatic cancer (PaCa) MiaPaCa2 spheres suggesting that RUNX2 is involved in PaCa-GEM (显示 GEM 抗体) resistance in presence of mutated p53 (显示 TP53 抗体).

  3. Runx2 overexpression effectively decreased TNF-alpha (显示 TNF 抗体)-induced Bax (显示 BAX 抗体) and cleaved caspase-3 (显示 CASP3 抗体) expression levels

  4. RUNX2 is one of the promising molecular targets for the treatment of the patients with pancreatic cancer regardless of their p53 (显示 TP53 抗体) status[review]

  5. we identified a novel missense mutation of RUNX2 in 2 patients by Whole exome sequencing and showed potential correlations between facial phenotypes and missense mutations in Runt (显示 RUNX1 抗体) domain through a mini-meta analysis.

  6. Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis.

  7. Results show that RUNX2 is highly expressed in bladder cancer tissues and are negatively correlated with miR (显示 MLXIP 抗体)-154 levels. This is likely through miR (显示 MLXIP 抗体)-154 binding the 3'-UTR (显示 UTS2R 抗体) of RUNX2 mRNA, promoting its degradation.

  8. Results identified a novel mutation besides the previously known in one patient with cleidocranial dysplasia (CCD). G462X mutation in exon 8 is located in the C-terminus of proline/serine/threonine-rich (PST (显示 SULT1A1 抗体)) domain. It might reduce the Runx2 transacting activity, lower the protein stability, downgrade the expression of bone marker genes, and eventually diminish osteoblast differentiation in CCD patients.

  9. Findings reveal a novel mechanism that Runx2 is transcriptionally regulated by HSP90 (显示 HSP90 抗体) via the AKT (显示 AKT1 抗体)/GSK-3beta/beta-catenin (显示 CTNNB1 抗体) signaling pathway, and by which leads to apoptosis of osteosarcoma cells.

  10. Increased baseline gene expressions of RUNX2, p21 (显示 CDKN1A 抗体) and caspase 3 (显示 CASP3 抗体) in the peripheral blood might predict better responses to methotrexate therapy.

Zebrafish Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Runx2 may have an evolutionarily conserved role in axis formation

Mouse (Murine) Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Results indicate that Dlx5 (显示 DLX5 抗体) and Runx2 are critical factors for the upregulated Osterix (显示 SP7 抗体) expression in shPP2A cells, which is considered to be important for the accelerated osteoblast differentiation in these cells.

  2. the expression of mouse Amtn gene in amelogenesis is mediated by Runx2/Cbfbeta complex. Runx2/Cbfbeta can bind to the two Runx2 binding motifs AACCACT (-1342/-1336) and AACCAAA (-98/-92) in the Amtn promoter and regulate Amtn gene expression.

  3. Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis.

  4. Puerarin may promote MC3T3E1 osteoblastlike cell viability and differentiation, which may be related to the downregulation of miR204 and the following activation of Runx2.

  5. mTOR (显示 FRAP1 抗体)/Raptor (显示 RPTOR 抗体) signaling is essential for bone formation in vivo through the regulation of Runx2 expression.

  6. these findings provide evidence that Cx43 (显示 GJA1 抗体) and Runx2 functionally intersect in vivo to regulate cortical bone properties and affect osteoblast differentiation and proliferation

  7. miR (显示 MLXIP 抗体)-133a-5p targets the 3' UTR (显示 UTS2R 抗体) of RUNX2 mRNA to regulate the expression of RUNX2 negatively.

  8. muramyl dipeptide directly augmented osteoblast differentiation and bone-forming gene expression by Runx2 activation.

  9. Loss of Runx1 (显示 RUNX1 抗体) and Runx2 inhibits prostate cell motility.

  10. fetal administration of Entinostat/MS-275, a class I histone deacetylase (HDAC (显示 HDAC1 抗体))-specific inhibitor, partially prevents delayed closure of cranial sutures in Runx2(+/-) mice strain of C57BL/6J by two mechanisms: 1) posttranslational acetylation of Runx2 protein, which stabilized the protein and activated its transcriptional activity; and 2) epigenetic regulation of Runx2 and other bone marker genes

Rabbit Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. The results suggest that gene therapy using Runx2-modi fi ed dental pulp stem cells was more effective during bone deposition and new bone formation in tibia Distraction osteogenesis.

  2. Runx2-modified adipose-derived stem cells promote tendon graft integration in anterior cruciate ligament reconstruction.

  3. The OPG (显示 TNFSF11 抗体) expression levels decreased while those of RANKL (显示 TNFSF11 抗体) and RUNX2 increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.

Xenopus laevis Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. These data also indicate that MGP (显示 MGP 抗体) is under dual regulation by runx2 through the use of various isoforms and context-dependent formation of transcriptional complexes.

Pig (Porcine) Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Klotho (显示 KL 抗体) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (显示 GRK4 抗体)-RUNX2 pathway.

RUNX2 抗原简介

蛋白简介

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

Gene names and symbols associated with RUNX2

  • runt related transcription factor 2 (RUNX2) 抗体
  • runt-related transcription factor 2a (runx2a) 抗体
  • runt related transcription factor 2 (Runx2) 抗体
  • runt-related transcription factor 2 (Runx2) 抗体
  • runt related transcription factor 2 (runx2) 抗体
  • runt-related transcription factor 2 (LOC703331) 抗体
  • runt-related transcription factor 2 (LOC100549663) 抗体
  • runt related transcription factor 2 L homeolog (runx2.L) 抗体
  • runt-related transcription factor 2 (RUNX2) 抗体
  • aml3 抗体
  • Cbf 抗体
  • CBF-alpha-1 抗体
  • Cbfa-1 抗体
  • cbfa1 抗体
  • ccd 抗体
  • ccd1 抗体
  • CLCD 抗体
  • LS3 抗体
  • OSF-2 抗体
  • osf2 抗体
  • pea2aa 抗体
  • pebp2a1 抗体
  • pebp2a2 抗体
  • pebp2aa 抗体
  • pebp2aa1 抗体
  • Pebpa2a 抗体
  • RUNX2 抗体

Protein level used designations for RUNX2

PEA2-alpha A , PEBP2-alpha A , SL3-3 enhancer factor 1 alpha A subunit , SL3/AKV core-binding factor alpha A subunit , acute myeloid leukemia 3 protein , core-binding factor, runt domain, alpha subunit 1 , oncogene AML-3 , osteoblast-specific transcription factor 2 , polyomavirus enhancer-binding protein 2 alpha A subunit , runt-related transcription factor 2 , transcription factor Runx2a , AKV core binding factor , CBF-alpha-1 , PEBP2 alpha A , core binding factor alpha 1 , runt domain, alpha subunit 1 , core-binding factor subunit alpha-1 , runt related transcription factor 2 , transcription factor Cbfa1 , runt-related factor 2 , core binding factor alpha 1 subunit , runt-related transcription factor 2-like , Runx2 spliced isoform , runt-related transcription factor 2 type I , runt-related transcription factor 2 type II

GENE ID SPECIES
860 Homo sapiens
405784 Danio rerio
12393 Mus musculus
367218 Rattus norvegicus
373919 Gallus gallus
445986 Takifugu rubripes
472017 Pan troglodytes
703331 Macaca mulatta
100008943 Oryctolagus cuniculus
100033890 Equus caballus
100080409 Ornithorhynchus anatinus
100189546 Xenopus (Silurana) tropicalis
100222668 Taeniopygia guttata
100406564 Callithrix jacchus
100453201 Pongo abelii
100549663 Meleagris gallopavo
100555776 Anolis carolinensis
100619969 Monodelphis domestica
100037059 Xenopus laevis
536911 Bos taurus
100737965 Sus scrofa
474923 Canis lupus familiaris
100734175 Cavia porcellus
100861217 Capra hircus
101115489 Ovis aries
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